Medication Errors in Chemotherapy PORSCHA L. JOHNSON, PHARM.D. CLINICAL PHARMACIST II MEDSTAR WASHINGTON HOSPITAL CENTER SATURDAY, SEPTEMBER 17, 2016
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1 Medication Errors in Chemotherapy PORSCHA L. JOHNSON, PHARM.D. CLINICAL PHARMACIST II MEDSTAR WASHINGTON HOSPITAL CENTER SATURDAY, SEPTEMBER 17, 2016
2 DISCLOSURE STATEMENT I have nothing to disclose regarding personal or professional affiliations or conflicts of interest to the course content presented. 2
3 LEARNING OBJECTIVES 1. Recognize medication errors associated with chemotherapy 2. Describe the magnitude of errors involving chemotherapy 3. Recall common causes of chemotherapy-related errors 4. Formulate strategies to encourage error reduction 5. Describe the role of the multidisciplinary team in error prevention 3
4 ADVERSE DRUG EVENTS ADEs are injuries that result from drug use May be preventable or non-preventable Potential ADEs result from medication errors with potential to harm, but: Are intercepted before reaching patient, or Reach patient do not cause harm 4
5 ERRORS IN MEDICATION MANAGEMENT PROCESS Ordering Transcribing Dispensing Administering Wrong dose Wrong drug Wrong route/form Allergy, Drug interaction Wrong route Wrong dose Wrong patient Wrong time Wrong drug Wrong dose Wrong route Wrong patient Wrong time Incorrect labeling/ Omitted Wrong route Primary catch for allergy, Drug interaction Wrong patient Wrong dose Wrong drug Wrong time/ Omitted Wrong route Frequently involves infusion pump Figure 1. Errors in medication cycle (National Council for Prescription Drug Programs). Am J Health-Syst Pharm. 2016;73(15):
6 CHEMOTHERAPY Biohazard to those preparing and administering the agents May cause adverse effects to any individual who comes in contact with the agents Special protocols required for preparation, administration, and disposal of chemotherapy Medication errors may cause harm to patients or practitioners 6
7 EXAMPLE Breast cancer patient prescribed Cyclophosphamide Ambiguous Order: 4 g/m 2 over 4 days Intended Cyclophosphamide Dose: 1 g/m 2 for 4 days Cyclophosphamide Dose Administered: 4 g/m 2 DAILY for 4 days Result: Fatal cardiac toxicity 7
8 COMMON CAUSES OF INCREASED ERROR RISK Complex chemotherapeutic regimens Multiple medications make up each regimen i.e., ACT Adriamycin plus Cyclophosphamide, followed by Taxol Chemotherapeutic agents combined with supportive therapies Antiemetics, colony-stimulating factors, etc. Each regimen may require 3-4 pre-meds for prevention of N/V or other adverse effects Some pre-meds may be administered by the patient at home 8
9 COMMON CAUSES OF INCREASED ERROR RISK Complex dosing calculations Dosing using body surface area (BSA) i.e., 1 g/m 2 daily Multiple-day regimens 1 g/m 2 daily given on days 1, 3, and 5 1 g/m 2 daily given every 2 weeks for 4 cycles Administration variability Same drug administered IV push, intermittent IV infusion, multiple-day continuous infusions Oral administration of IV or SQ products 9
10 COMMON CAUSES OF INCREASED ERROR RISK Non-standard nomenclature Use of abbreviations AC (A)driamycin and (C)yclophosphamide CHOP (C)yclophosphamide, (H)ydroxydoxorubicin, (O)ncovin, (P)rednisone Non-standard or Investigational protocols Dosing protocols may not be available in published textbooks for verification 10
11 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 11
12 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 12
13 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 13
14 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 14
15 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 15
16 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 16
17 STRATEGIES FOR ERROR REDUCTION Educating health care providers Verifying the dosage Establishing dosing limits Standardizing Working with pharmaceutical manufacturers (problems with labeling) Educating patients Improving communication 17
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