Cobimetinib (Cotellic ) ( koe-bi-me-ti-nib )
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1 Cobimetinib (Cotellic ) ( koe-bi-me-ti-nib ) How drug is given: by mouth Purpose: to stop the growth of melanoma cancer cells How to take this drug 1. This drug can be taken with or without food. 2. Swallow each tablet whole; do not crush or chew them. If you have trouble swallowing the tablet, the pharmacist will give you specific instructions. 3. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double dose. Storage and disposal 1. Store at room temperature, away from heat and moisture. 2. Keep this medicine in its original container, out of reach of children and pets. 3. If you have unused oral chemotherapy pills (tablets or capsules), please return them to the pharmacy where the prescription was filled. Do not flush them down the toilet, dump in the sink, or throw away in the trash. Things that may occur during or after treatment 1. Mild to moderate nausea, vomiting, and loss of appetite may occur. You may be given medicine to help with this. 2. Loose stools or diarrhea may occur within a few days after the drug is started. You may take loperamide (Imodium A-D ) to help control diarrhea. You can buy this at most drug stores. Be sure to also drink more fluids (water, juice, sports drinks). If these do not help within 24 hours, call your cancer care team. Last Revised 04/2016 Patient and Family Education Committee
2 Cobimetinib Page 2 of 3 3. Your blood pressure may go up. If this happens, you may be given medication to help with this. If you have headaches, dizziness, or feel weak, let your cancer care team know right away. 4. Your skin may be more sensitive in the sun. Use a sunscreen of SPF 30 or higher when you go outside. Do not go to tanning booths. Skin changes such as dryness or a rash on your body may occur. Your skin may feel warm. Ask your cancer care team what lotions or creams you may use. 5. Your blood cell counts may drop. This is known as bone marrow suppression. This includes a decrease in: Red blood cells, which carry oxygen in your body to help give you energy White blood cells, which fight infection in your body Platelets, which help clot the blood to stop bleeding If you have a fever of F (38 C) or higher, chills, a cough, or any bleeding problems, call your cancer care team right away. 6. Some important minerals called electrolytes are found in your blood and body fluids. They can be affected by this medicine. Your cancer care team will check your blood work periodically to monitor your potassium, magnesium and sodium levels. 7. Your liver may be affected by this drug. On occasion, blood work will be taken to monitor your liver function. 8. You may have blurred vision or notice other changes in your vision. Talk to cancer care team about what might help with this. 9. Some patients may feel very tired, also known as fatigue. You may need to rest or take naps more often. Mild to moderate exercise can also help you maintain your energy. 10. You may be at increased risk for bleeding. Call your cancer care team if: You see blood in your urine or stool You feel dizzy or faint 11. This drug may affect your heart. Your heart function will be followed. You should tell your cancer care team if you are coughing, having trouble breathing, have chest pain, and/or have swelling in the feet or ankles. 12. You may feel stiffness, pain, or weakness in your muscles. In rare cases, this may lead to severe muscle damage called rhabdomyolysis (pronounced rab-doe-my-o-lie-sis ). Your cancer team will use blood tests to monitor muscle proteins. 13. You are at risk of getting another type of skin cancer. If you notice any skin changes, call your cancer team. Last Revised 04/2016 Patient and Family Education Committee
3 Cobimetinib Page 3 of 3 Things that may occur after treatment ends (even months to years later) Fertility and related precautions: It is very important to use birth control if you are having sex, because this drug may be harmful to an unborn baby. Women should not breastfeed while receiving this drug. If you are concerned about any of this, please talk with your cancer care team. The information in this document includes some but not necessarily all of the possible side effects of this medication. The side effects listed in this teaching sheet may not be the same ones you experience. Your side effects may be different depending on how often you receive treatment (your schedule) and how much you receive each time (your dosage). Side effects may also vary if you are taking other medications. Please speak with your doctor or nurse if you have questions about possible side effects you may experience. This document should not take the place of conversations with members of your health care team. If you experience a change in your health during or after treatment, contact a member of your health care team right away. Managing your oral chemotherapy schedule at home can be challenging. To help you with this, consider using tools to help you keep track of your schedule and any side effects you may have. You can find these tools online at THIS SPACE RESERVED FOR WRITTEN COMMENTS OR NOTES FOR THE PATIENT AND FAMILY: Last Revised 04/2016 Patient and Family Education Committee
4 Oral Chemotherapy Fact Sheet Oral chemotherapy medicines are given by mouth in the form of capsules, tablets, or liquid. These safety tips will help you understand what to do when you are taking oral chemotherapy. Please note: If you are on a clinical trial, you may be given special instructions. How to take this drug Swallow each tablet or capsule whole. Do not break, crush, or chew. Prepare your drug away from food and food prep areas. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose. If you are on a clinical trial, you will be given special instructions if you miss a dose. If you are unable to swallow the pill, speak with your nurse or pharmacist about other ways to take your medication. If you vomit or throw up your medication, call your physician for further instructions. Wash your hands after taking the medication. Avoid handling crushed or broken pills (tablets or capsules). Storage Most oral chemotherapy medicine is stored at room temperature, away from excess heat and moisture. You will be told if the medication you are taking needs special storage or handling. Keep this medicine in its original container, in a safe place, away from other family medications. All medications need to be kept out of the reach of children and pets. Last Revised 3/2015 Patient Education Committee
5 Oral Chemotherapy Fact Sheet Page 2 of 3 Disposal If you have unused oral chemotherapy pills (tablets or capsules), please return them to the pharmacy where the prescription was filled. Do not flush down the toilet, dump in the sink, or throw away in the trash. Safe handling of body waste in the home after chemotherapy Chemotherapy stays in the body for hours or even days, and is found in vomit, urine, stool, and sweat (body wastes). Special care must be taken to prevent the patient s body waste from coming into accidental contact with the patient or caregiver. Body wastes Patient and caregiver: You can use the toilet (septic tank or city sewage) as usual. There is no research to support double flushing to prevent accidental contact (although this may be suggested for certain medications). Ask your doctor or nurse what they suggest for your medication. Wash your hands well with soap and water after using the toilet. If urine, vomit, or stool gets on your body, wash with soap and water. Always wear gloves when cleaning equipment or disposing waste from a urinal or commode. Pregnant caregivers should not handle patient body waste. It is safe for family and friends to use the same toilet, as long as all body waste is cleaned from the toilet. To absorb urine or stool, use a disposable, plastic-backed pad, diaper, or sheet. Change it immediately when soiled. Then wash skin with soap and water. If you have an ostomy, you or your caregiver may want to wear gloves when emptying or changing appliances. Laundry Always wear disposable gloves when handling sheets or clothes that have been soiled with body waste. Soiled items should be kept and washed separately from the other laundry. Oral chemotherapy is a serious drug that requires extra caution. If you have questions or concerns about your oral chemotherapy, do not hesitate to call your clinician. For more tips, tools and short videos to help you manage oral chemotherapy visit our web page at Last Revised 3/2015 Patient Education Committee
6 Oral Chemotherapy Fact Sheet Page 3 of 3 Managing your oral chemotherapy schedule at home can be challenging. To help you with this, consider using tools to help you keep track of your schedule and any side effects you may have. You can find these tools online at The materials included on this page are for informational purposes only. The content is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. THIS SPACE RESERVED FOR WRITTEN COMMENTS OR NOTES FOR THE PATIENT AND FAMILY: Last Revised 3/2015 Patient Education Committee
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