Genome Canada Large Scale Applied Research Project 2015 Natural Resources and the Environment: Sector Challenges Genomic Solutions

Transcription

1 Genome Canada Large Scale Applied Research Project 2015 Natural Resources and the Environment: Sector Challenges Genomic Solutions Micheline Ayoub Stéphanie Lord-Fontaine

2 ROLE OF GÉNOME QUÉBEC Génome Québec is part of 6 genomics centers in Canada that support genomics research in their respective region For Genome Canada Competitions, we: Help candidates to prepare competitive applications Facilitate the access to innovation and technology centers and other service providers Once projects are approved, GQ does project management and oversight Ensure the competitiveness of Quebec researchers 2

3 COMPETITION BACKGROUND Using applied genomic approaches to address challenges and opportunities of importance to Canada s natural resources: Wildlife management/conservation Forestry, energy, mining Water stewardship Bioproducts that help conserve natural resources and protect the environment 3

4 Need for : COMPETITION BACKGROUND Concrete deliverable(s): by the end of the funding period (new procedures/services, products, assays ) not only high impact publications, creation of database, new scientific knowledge, training of HQP Detailed translation plan into significant social and/or economic benefits within as short a time-frame as possible 4

5 Application of genomics (omics) $26M from GC Financing scheme: COMPETITION BACKGROUND 1/3 GC 1/3 GQ 1/3 others Max GC contribution $3.33M GQ $ for expenses within the province (MEIE funds) Projects lead by other provinces: GQ will provide 1/3 of the funds for the QC portion of the budget 5

6 COMPETITION BACKGROUND Total / project : $2M - $10M (>10M$ if more cofunding) Duration: max 4 years Active End user engagement to ensure deliverables uptake: collaborators, co-applicants, translational committee members 6

7 End users: COMPETITION BACKGROUND industry, government departments, regulatory agencies, service providers, municipalities 7

8 Examples of topics : ELIGIBLE RESEARCH THEMES enable increased recovery and greener extraction and processing in the mining and energy sectors genomic solutions to increase forest productivity and sustainability selecting commercially desirable trees understanding and controlling forest pests, diseases, and invasive species; development of renewable resources, water (marine and fresh) stewardship 8

9 Examples of topics : ELIGIBLE RESEARCH THEMES understanding of the effect of climate change vectors and vector-borne diseases effect of climate change on the introduction of foreign invasive species into Canada (impact on biodiversity and wildlife populations) environmental toxicogenomics genomic approaches to a better description and understanding of biological diversity (for biomonitoring) remediation of contaminated environments. 9

10 Genomics and its ethical, environmental, economic, legal and social aspects Two forms of GE 3 LS research Large genomics projects integrated GE 3 LS Large-scale GE 3 LS projects 10

11 INTEGRATED GE 3 LS Mandatory research component for each project (objectives, methods, deliverables) Strategically chosen applied research component complementary and specific to each project, with associated budget Close collaboration with GE 3 LS community (social sciences/humanities) to support translation of research deliverables into socio-economic benefits Examples Regulatory challenges associated with deliverable uptake, Public acceptance of product or assay or technology. 1 1

12 Large-scale GE 3 LS Large-scale research project Investigation of major opportunities and/or obstacles directly related to programme objectives Active collaboration and regular interaction with genomics community Interaction with other large-scale or integrated GE 3 LS projects Examples investigating the effects of the application of genomics on international trade and market access to exports of Canadian natural resource products; and, exploring the effects of national policies and/or regulations on the uptake of genomicsbased applications and the impact on sector competitiveness and productivity. 1 2

13 TIMETABLE Actions Génome Québec Genome Canada Launch 04 June 2015 Registration 31 July August 2015 Pre-applications Friendly reviews 17 September 2015 (Sept 28, 29, 20 Oct 1) 10 November 2015 Pre-applications results Late January 2015 Full applications Friendly review Rehearsal of presentation 4 March 2016 March 9, 10, Mid May (TBD) 14 April 2016 GC Review committee meets (including with applicants) Late May 2016 Notice of decision (NOA) Late June 2016 Transfer of funds October

14 HOW TO Registration (31 July 2015 GQ) Mandatory but not a selection step: Eligibility screening Applicants ID Research Areas Approximate budget One page research summary Suggestions for reviewers Project leader Names and project title will be posted on the web possibility for collaboration/merge Project leader names cannot change after this step 14

15 Pre-Application (17 september 2015 GQ) : About 15 pages Summary HOW TO Team (short CV for 5 members) Research Project : Integrated GE 3 LS Description of deliverables (GANTT) End user engagement Socio-economic benefits for Québec & Canada High level Budget per activity and co-funding plan GQ: FRIENDLY PEER REVIEW (SEPT 28 OCT 1) GC: SELECTION 15

16 HOW TO Full Application (4 March 2016 GQ): about 50 pages Summary Team Research Project : Integrated GE 3 LS Description of deliverables (GANTT) End user engagement Socio-economic benefits for Québec & Canada Detailed Budget per activity and category, co-funding plan and supporting documents Management GQ: FRIENDLY PEER REVIEW (MARCH 9-11) GC: SELECTION 16

17 EXPECTED SUCCESS RATE Canada (Quebec) 78(19) Registrations 54 (12) Pre-Applications NOT an LOI : Critical step 27 (7) Full Applications? (?) funded projects 17

18 EVALUATION CRITERIA Quality of team, multidisciplinarity Omic expertise GE 3 LS expertise Scientific excellence/originality Technical feasibility with supportive POC data Alignment to a need and concrete deliverables Socio-economic impact (short term) National/provincial/international impact End users engagement and role in translation plan Knowledge transfer/commercialization plan 18

19 COFUNDING & EXPENSES CFI eligible BUT not NSERC, centers of excellence, Canada research chair NRCan, EC, NRC, DFO, AAFC, CFIA and other federal labs : eligible Co-funding covered expenses can be eligible 6 months before NOA Cash or in kind (non-cash eligible budget items which can be given a cash value) Equipments BUT not construction, rent or renovation Suppliers discounts are not eligible GQ $ not to federal, provincial laboratories nor private GC $ OK to provincial laboratories but not OK to fed labs or private Genome Canada Guidelines for Funding Genomics Research Projects 19

20 WHAT WE WILL DO WITH YOU White board sessions strategic discussions Friendly peer review sessions (at various seps): what is it? Networking and partnerships Drafting sessions, instructions for various sections, budget preparation Contact with other Genome Centers across Canada Financial support possible for applicants (TBC) Administrative support (review formats of applications ) 20

21 OUR ADVICE START NOW 21

22 Genomic applications partnership program (GAPP) Diane Bouchard, Génome Québec

23 PROGRAM OBJECTIVES Academia Users Promote the application of genomics derived solutions to address key sector challenges or opportunities Enable the transfer of genomics-driven solutions from academia to users Increase the socioeconomic value of genomics research Foster productive interface between end-users and academic research 23

24 PARAMETERS UP TO $38 MILLION IS AVAILABLE FROM GENOME CANADA $300,000 to $6 million in total project budget ⅓ of the total investment in the project will be funded by Genome Canada ⅙ will be funded by Genome Québec The remaining ½ must be secured through co-funding Project duration: 6 months to a maximum of 3 years 24

25 Disruptive Innovation in Genomics Cristina Ciurli, Génome Québec

26 WHAT IS IT? A new genomics-based technology; The application of an existing technology from another field, applied to the field of genomics, with potential to: either displace an existing technology, disrupt an existing market or create a new market; offers the capability to do things not previously possible; Not just an incremental improvement of an existing technology. Launch date: June 11,

27 MODEL AND FINANCING SCHEME Phase 1: Feasibility of an idea does this technology work and what can it do? No co-funding required Total per project: $250K (~$5M total envelope) Duration: 24 months Phase 2: Support the development of a prototype (process, product and/or method) advancing the idea. Financing: 1/3 GC 1/3 GQ 1/3 others Total per project : $3M (~$10M total envelope) Duration: 2-3 years 27

28 GÉNOME QUÉBEC TEAM Natural Resources and Environment Micheline Ayoub Tel: , x251 Stéphanie Lord-Fontaine Tel: , x204 DIG Cristina Ciurli Tel: , x241 GAPP Diane Bouchard Tel: , x236 28

29 Innovation Center Daniel Tessier, Vice-president Technology Centres

30 McGill University and Génome Québec Innovation Centre Multiple applications: Whole genome sequencing Exome sequencing (custom capture) RNA-Seq ChIP-Seq Epigenetics, methylation Transcriptomics, expression Genotyping (GWAS and custom) Validation (low throughput sequencing and genotyping) Bioinformatics Data analysis 30

31 630 RenØ-LØvesque Blvd West, Suite 2660 MontrØal (QuØbec) H3B 1S