Edward Bruce-White CEO Combat Medical Ltd. How to Access Funding.

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1 Edward Bruce-White CEO Combat Medical Ltd How to Access Funding

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4 Combat Medical History Developed 2 innovative hyperthermic drug delivery systems for Bladder & Peritoneal Cancer Both potential game changers in 1bn+ markets (Addressable market conservatively 2bn+) Both bladder and peritoneal systems CE Marked and first clinical patients ,000+ HIVEC (Bladder) treatments completed to date 400+ HIPEC (Peritoneal) treatments completed to date

5 Combat Medical History (continued) Sales of 1m for Year Ended May 2016 Strong growth & gross margins 20 countries now signed up with exclusive agreements (30+ end of 2016) Launch in China & US in 2017 in talks with large exciting companies Well established business model Combat has an outstanding Board, Management team and Clinical Advisory Board 4 patents owned - 2 granted Further R&D well advanced in pre-clinical stage for improved therapies and drug delivery and expected to create at least 2 more patents. Awards: UK-China Innovation is Great, Oxford Trust Innovation, Shanghai International Innovation

6 Combat Medical BRS System Innovation - Combination - Integration

7 Summary of clinical benefits of Combat s Technologies Significantly reduce recurrence Improves survival rates and quality of life Fits in with existing practises and easy to adopt Reduces the overall treatment cost (affordable) Improve the absorption of the chemotherapy Stimulates the body s own immune response Allows the delivery of chemotherapy with little added toxicity and excellent patient tolerability Targeted delivery to just specific organ and cancer cells thereby minimising the rest of the body s exposure Has the potential to work with other drugs to enhance performance

8 BLADDER RECIRCULATION SYSTEM - BRS

9 Combat s Journey... The big idea well at least the first of many to 2010 (Spain) - Developed IP, proof of concept, built first system and completed all initial tests. Gain CE mark and first patients in Spain start of First publication 3 April 2014! We did this the hard way and on our own... After good initial results we identified we need large clinical trials to become a standard of care.so we need a lot money and people 2012 Combat moved to UK UK plc 1% worlds population, 3% of GDP and is responsible for 16% of world innovation. Raise funding - 60% of European venture funding comes from UK because SEIS, EIS, VCT fund scheme Potential access to more grants More innovative environment - Medtech Campus, Knowledgeable Angel investor networks, Venture Fest, SEHTA Better Corporate tax advantages R&D tax credits, patent box Better access to highly qualified professionals Better perception Internationally Did it work and what happened?

10 Funding to date Funding Founders invested significantly to develop technology platform. Raised 3.3m in 4 rounds from UK SEIS/EIS & Hong Kong Investors. 70,000 ERDF with help of Medtech Campus. 100,000+ R&D tax credits Applying for 5m+ in grants (UK, US & Chinese) Currently fund raising for up to 3m for accelerated commercialisation to and supercharge further R&D and clinical work.

11 Combat s experience of accessing various type of finance.. Personal Mortgage the house, friends & family Angel Investors (SEIS & EIS) High Net worth UK & foreign investors Smaller Specialist EIS funds Larger EIS & VCT funds (government supported) Specialist funds - renewal energy Foreign investment (Chinese) Crowd Funding Banks Traditional & European IPO Private equity Brokers Oxford Innovations

12 Grants & other types of financial support Innovation hubs and centres.now appearing UKTI Grant Innovate UK (Enterprise Europe) European Reg Dev Fund (ERDF) Meditech Eurostars Horizon 20:20/SMART NIHR i4i University affiliations & hubs (UCLH, Medcity, SEHTA, Kent, Surrey, Sussex, Anglia Ruskin, Imperial) SBRI CRUK Foreign investment grants Newton Fund Chinese local investment incentives US (massive amount available 56bn but you need to find partner)

13 Planning to win grants So we know there are large pots of cash available but there is a lot of confusion and mystification. Combat won grant 70k low carbon Applying for grants needs forward planning and hard work to make a successful application, it takes around 100 hours work to make a good application..it is a lottery. Collaboration & good partners. Average success rates varies between 10-35%. There is little help available in making applications. PNO Consultants (Europe), Freemind consultants (US) & Specialist consultants

14 Did the move to the UK work? YES So far UK PLC has provided an excellent platform for Combat Initiatives and networks such this are essential and bring value So if at first you don t succeed try, try, try again!