Overview of the Congressionally Directed Medical
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1 US Army Medical Research and Materiel Command (USAMRMC) Overview of the Congressionally Directed Medical Research Programs (CDMRP) Presented by Melissa A. Forsythe, Ph.D. Colonel, U.S. Army (Retired) Program Manager, CDMRP 1
2 Who is the CDMRP? 2
3 Origins of the CDMRP In the early 1990s, grassroots advocacy efforts heightened political awareness of breast cancer In 1993, Congress appropriated $235M to the DOD budget for the Breast Cancer Research Program (BCRP) USAMRMC was directed to manage the BCRP Institute of Medicine consulted 3
4 CDMRP History : Neurofibromatosis 1997: Prostate Cancer and Ovarian Cancer 1999: Peer Reviewed Medical 2002: Prion, Tuberous Sclerosis, and Chronic Myelogenous Leukemia 2006: Gulf War Illness 2007: Amyotrophic Lateral Sclerosis, Autism, and Psychological Health/Traumatic Brain Injury 2008: Deployment Related Medical, Bone Marrow Failure 2009: Genetic Studies of Food Allergies, Lung Cancer, Multiple l Sclerosis, Orthopaedic, Peer Reviewed Cancer, and Spinal Cord Injury 4
5 What is the CDMRP? The second largest research funding source for: Breast Cancer Prostate Cancer Ovarian Cancer 5
6 Additional CDMRP Cancer Research Programs Lung Cancer Research Program Peer Reviewed Medical Research Program Mesothelioma Neuroblastoma Pheochromocytoma Peer Reviewed Cancer Research Program Blood cancers Colorectal cancer Genetic cancer and genomic medicine Kidney cancer Listeria vaccine for cancer Melanoma and other skin cancers Pediatric brain tumor Radiation protection using nanotechnology 6
7 Additional i CDMRP Research Programs Autism Bone Marrow Failure Genetic Studies of Food Allergies Multiple Sclerosis Neurofibromatosis Tuberous Sclerosis Complex 7
8 CDMRP Military Relevant Programs Amyotrophic Lateral Sclerosis Gulf War Illness Peer Reviewed Orthopaedic Psychological Health/Traumatic Brain Injury Spinal Cord Injury Peer Reviewed Medical Research Program Chronic Migraine and Posttraumatic headache Dystonia Drug Abuse Listeria Vaccine Epilepsy Post-traumatic Osteoarthritis Tinnitus Paget s Disease 8
9 Scope of CDMRP Funds and Awards Defense Women's Health Osteoporosis 700 National Prion Cooperative DOD/VA Medical 600 Myeloproliferative Disorders Genetic Studies of Food Allergies Deployment Related Medical 500 Psychological Health/Traumatic Brain Injury Bone Marrow Failure Millions ($) Multiple Sclerosis Peer Reviewed Cancer Lung Cancer Peer Reviewed Orthopaedic Spinal Cord Injury 200 Gulf War Illness Amyotrophic Lateral Sclerosis Autism 100 Tuberous Sclerosis Chronic Myelogenous Leukemia 0 Institutionally Based Programs Peer Reviewed Medical Ovarian Cancer Proposals Received since 1992: 68,175 Proposals s Funded since 1992: 9,515 5 Neurofibromatosis Prostate Cancer Breast Cancer 9
10 CDMRP-Funded Awards Rate % Nu umber of Preprop posals, Proposa als and Awards % 30% 25% 20% 15% 10% 5% 0% Percent tage of Proposal ls Funded Data as of end of FY 2009 Preproposals Proposals Awards rate 10
11 CDMRP-Sponsored Conferences Era of Hope 1997, 2000, 2002, 2005, 2008, , 2006, ,
12 Hallmarks of CDMRP Funds added to DOD budget by Congress (disease-specific) Vision i is adapted d yearly, and award mechanisms are changed as needed Two-tier formal review of proposals Consumer advocates involved throughout h t process Fund highly innovative research Unique peer review: No standing panels No contact between reviewers and applicants Funding flexibility No pay line; funding recommendations based on portfolio balance, relative innovation, and impact Funds obligated up front; no out-year budget commitments No continuation funding 12
13 Partnerships Advocates Demonstrate need Participate at all levels Passion and perspective Congress Add funds to budget Targeted guidance Opportunity to leverage Researchers Innovation and gaps Risk/Benefit Product-oriented IMPROVE HEALTH (CURE) DOD Program management Regulatory and budget requirements IOM model 13 13
14 Advocates, Consumers, and the CDMRP More than 100 consumers have served on Integration Panels ~1000 consumers have served on peer review panels Panel members... Contribute unique personal and community experiences Add perspective, passion, and a sense of urgency Ensure that human dimensions of disease are incorporated into: Scientific considerations Program policy Investment strategy Research focus Take information and a greater understanding of the scientific process back to community Provide hope to survivors and family members 14
15 Scientific Backbone ~ 7,200 scientists and clinicians have brought technical expertise to peer review panels ~ 500 world-renownedrenowned scientists, clinicians, and policymakers have served on Integration Panels More than 250 scientists have served as ad hoc programmatic reviewers Nearly 7,000 scientists and clinicians funded ~ 130 scientists, clinicians, and professionals currently manage the CDMRP 15
16 CDMRP Program Cycle Congressional Appropriation Receipt of Funds Vision Setting Month 1-4 Release of Program Announcement Month 2-5 Candidate Award List Negotiations USAMRAA ORP Issues Human/Animal Use Other Peer/Programmatic Review Issues Grant Awarded Grant Management USAMRAA ORP CDMRP Commanding General e Approval Month Grant Closeout Programmatic Review Month 9-14 Peer Review Month 7-11 Research Outcomes Database Congress Stakeholders Integration Panel Proposal Receipt Month 7-11 Invitation to Submit Preproposal Receipt Month 5-8 Preproposal Screening Month 5-8 Month
17 Innovative Review Processes: Two-Tier Ti Review Goal: To find scientifically meritorious and innovative proposals, and fund those that best fulfill program goals Peer Review Panels Partnership Integration Panel Peer Review Programmatic Review Evaluation of scientific merit Evaluation of programmatic relevance Criteria-based evaluation Comparison-based evaluation Proposals evaluated within related disciplines Proposals evaluated across multiple disciplines Products: Product: Proposal scoring Summary statements List of funding recommendations for the Commanding General, USAMRMC 17 17
18 Scientific Peer Review Panels Diverse composition: Consumer advocates Scientists from military, academia, and industry Clinicians from military, academia, and private practice Stringent reviewer expertise standards Composition not made known to applicants No standing panels No contact between applicants and panel members 18
19 Innovative Review Processes: Integration ti Panel Recommending body to the CDMRP Recommends a program focus Provides input for dissemination i of information Assists in policy development Recommends a research investment strategy Programmatically evaluates research proposals 19
20 Membership of the Integration Panel Consumers Integration Panel Scientists Providers 20
21 Vision Setting Process Vision Investment Strategy 21
22 Each CDMRP program addresses critical issues for the research and patient communities through different funding opportunities 22
23 Programmatic Review Process Robust Discussion of Applications Innovation Impact Risk vs. Gain Basic Translational Vision Program Priorities Funding Recommendations 23
24 Award Mechanisms Pipeline Development of Ideas Early Ideas Clinical/Translational Clinical Trials Concept Pilot Hypothesis Development More Mature Ideas Idea Development Investigator- Initiated Translational Research Partnership Therapeutic Development Advanced Technology/ Therapeutic Development Team Science Synergistic Idea Program Project Consortium Centers of Excellence 24
25 Award Mechanisms Pipeline (continued) Career Development Training Early Career Established Distinguished Predoctoral Postdoctoral Institutional Training HBCU/MI Fellowship New Investigator Career Development Era of Hope Postdoctoral Era of Hope Scholar Investigator Initiated Idea Development Innovator Impact 25
26 High Impact High Risk/High Gain Research CDMRP to Cancer Research Leapfrog Research Advances Programs 26
27 Breast Cancer Research Program (BCRP) Program Vision: To eradicate breast cancer by funding innovative, high- h Congressional impact research through a partnership Appropriation of scientists and consumers FY92-09 $2.3B FY10 $150M 27
28 28 DOD Congressionally Directed Medical Research Programs Intent: FY10 BCRP Inter-Institutional I tit ti ltraining i Award Supports two or more faculty-level investigators at an organization that does not currently have a breast cancer research program to acquire mentored training in breast cancer research Supports the establishment t of a sustainable breast cancer research program at the applicant organization Key Features: Maximum period of performance is 4 years Maximum allowable funding for the entire period of performance is $1M in direct costs Submission i deadlines: dli Letter of intent due 13 May Applications due 27 May
29 Intent: FY10 BCRP Concept taward Supports untested, high-risk questions relevant to breast cancer Key Features: Preliminary data not allowed Open to investigators at all academic levels Maximum period of performance is 1 year Maximum allowable funding for the entire period of performance is $75K in direct costs Submission deadlines: Letter of intent t due 12 May Applications due 27 May 29
30 Prostate Cancer Research Program (PCRP) Program Vision: To conquer prostate cancer Congressional Appropriation FY97-09 $970M FY10 $80M 30
31 FY10 PCRP Training Awards Intent: Supports training in prostate cancer research for early career individuals; Awards focused on Health Disparity also available Key Features: PIs must have a designated mentor experienced in prostate cancer research Emphasis on PI, Mentor, Training, and Environment Applicants Duration Funding Predoctoral (Ph.D. or M.D./Ph.D.) 3 years $92.5K Postdoctoral (Ph.D. or M.D.) 2 years $115K *M.D. (Physician Research Training) 3-5 years $130K/year * Includes 40% protected time for research Submission deadlines: Letter of intent due 5 May Applications due 26 May 31
32 FY10 PCRP Research Awards Award Intent Eligibility Health Disparity Research Population- Based Research Laboratory- Clinical Transition Support innovative research projects focused on prostate cancer health disparities Support acquisition of unique information and/or tools for prostate cancer research using statistical analyses of defined population(s). Support goal- and product-driven preclinical studies of promising lead agents for prostate cancer At or above Assistant Professor level At or above Assistant Professor level At or above Assistant Professor level Funding/ Duration $450K 3 years $600K 4 years $750K 3 years Submission deadlines: Letter of intent due 5 May Applications due 26 May 32
33 Peer Reviewed Cancer Research Program (PRCRP) Program Vision: To improve the quality of life by decreasing the impact of cancer on service members, their families and the American public Congressional Appropriation FY09 $16M FY10 $15M 33
34 PRCRP Topic Areas Melanoma and other skin cancers Pediatric brain tumors within the field of childhood cancer Genetic cancer research and genomic medicine Blood Cancers Colorectal Cancer Kidney Cancer Listeria vaccine for cancer Radiation protection utilizing nanotechnology 34
35 FY10 PRCRP Concept taward Intent: Supports the exploration of a highly innovative new concept or untested theory Key Features: Preliminary data not allowed Open to investigators at all academic levels Maximum period of performance is 1 year Maximum allowable funding for the entire period of performance is $75K in direct costs Anticipated Program Announcement (PA)Release: May/June
36 Intent: FY10 PRCRP Idea Award Supports the exploration of ideas that are still in the early stages of development Key Features: Preliminary data not required Open to investigators at all academic levels Clinical trials not allowed Collaborative Option supports up to 3 investigators Maximum period of performance is 3 years 36 Maximum allowable funding for the entire period of performance is $375K in direct costs, $750K for applications with Collaborative Option Anticipated PA Release: May/June 2010
37 FY10 PRCRP Translational lnew Investigator t Award Intent: Supports the development of translational research collaborations between independent new investigators and a mentor Key Features: Either the new investigator or the mentor must be a clinician Preliminary data not required Clinical trials not allowed Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $300K in direct costs Anticipated PA Release: May/June
38 FY09 PH/TBI Research Program CDMRP Military US Army Medical Relevant Research and Materiel Programs Command
39 Gulf War Illness Research Program (GWIRP) Program Vision: i Improve the Congressional Appropriation health and lives of veterans who have Gulf War Illness FY94-09 $235M FY10 $8M 39
40 40 DOD Congressionally Directed Medical Research Programs Intent: FY10 GWIRP Investigator-Initiated t I iti t Research haward Supports new ideas in basic and clinical developmental research Key Features: Preliminary data are not required Clinical trials are not allowed Open to investigators at all academic levels Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $600K in direct costs Submission deadlines: 2 page preproposal due 14 May Applications due 4 August, by invitation only
41 41 DOD Congressionally Directed Medical Research Programs Intent: FY10 GWIRP Innovative Treatment t Evaluation Award Supports exploratory or small scale studies evaluating treatments previously not studied in GWI Key Features: Preliminary i data are not required Pilot Phase II or Phase I/II trial combinations are permitted Open to investigators at all academic levels Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $450K in direct costs Submission deadlines: 2 page preproposal due 14 May Applications due 4 August, by invitation only
42 FY10 GWIRP Clinical i l Trial Award Intent: Supports Phase II or III clinical trials focusing on treatments for GWI Key Features: Preliminary/preclinical data are required Open to investigators at all academic levels Maximum period of performance is 4 years Maximum allowable funding for the entire period of performance is $1.5M in direct costs Submission deadlines: 2 page preproposal due 14 May Applications due 4 August, by invitation only 42
43 Intent: FY10 GWIRP Consortium Development taward Supports initial development of infrastructure and collaborations for a multi-institutional consortium for GWI research Key Features: Awardees expected to apply for FY11 Consortium Award Award funds consortium development, not research Open to investigators at all academic levels Maximum period of performance is 1 year Maximum allowable funding for the entire period of performance is $200K in direct costs Submission deadlines: Letter of intent due 14 May Applications due 4 August 43
44 Peer Reviewed Orthopaedic Research Program (PRORP) Congressional Appropriation Program Vision: Provide all Warriors affected by FY09 orthopaedic injuries sustained in the defense of our Constitution the $112M opportunity for optimal recovery and restoration FY10 of function $22.5M 44
45 45 DOD Congressionally Directed Medical Research Programs FY10 PRORP Career Development taward Intent: Provides support to military (active duty) investigators at an early career stage Key Features: Requires mentorship by an established orthopaedic researcher Must address focus areas as listed in Program Announcement Preliminary data not allowed Open to active duty military investigators with less than 8 years total postdoctoral clinical or research experience Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $225K in direct costs Anticipated PA Release: May/June 2010
46 FY10 PRORP Rehabilitation ti Clinical i l Consortium Award Intent: Provides support to develop collaborations, resources, and infrastructure necessary for a consortium of institutions to rapidly execute clinical studies Key Features: Requires collaboration with military treatment facilities listed in Program Announcement Open to investigators t at or above level l of fassociate Professor Maximum period of performance is 5 years Maximum allowable funding for the entire period of performance is $19.5M in direct costs Anticipated PA Release: May/June
47 CDMRP Neuroscience Research Programs High Risk/High Gain Research Innovative Research to Leapfrog Advances 47
48 Amyotrophic Lateral Sclerosis Research Program (ALSRP) Program Vision: Improve treatment and C i l find a cure for ALS Congressional Appropriation FY07-09 $10M FY10 $7.5M 48
49 49 DOD Congressionally Directed Medical Research Programs Intent: FY10 ALSRP Therapeutic Idea Award Supports early stage research relative to novel therapeutic development for ALS Key Features: Preliminary i data are not required Innovation and Impact are primary criteria Open to investigators at all academic levels Maximum period of performance is 2 years Maximum allowable funding for the entire period of performance is $400K in direct costs Submission deadlines: 2 page Preproposal due 14 May Applications due 4 August by invitation only
50 FY10 ALSRP Therapeutic Development Award Intent: Supports preclinical development of therapeutics for ALS Focus Areas: Development of high-throughput screens up to the submission of IND for later clinical trials Key Features: Preliminary data required Open to investigators at all academic levels Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $1.5M in direct costs Submission deadlines: 2 page Preproposal due 14 May Applications due 4 August, by invitation only 50
51 Neurofibromatosis Research Program (NFRP) Program Vision: To find and fund the best research to eradicate the clinical impact of NF Congressional Appropriation FY96-09 $200.3M FY10 $13.75M 51
52 FY10 NFRP Exploration-Hypothesis th i Development taward Intent: Supports the initial exploration of innovative, untested research Key Features: Preliminary data is encouraged but not required Open to investigators at all academic levels Human subjects research must be exempt or eligible for expedited review Maximum period of performance is 2 years Maximum allowable funding for the entire period of performance is $100K in direct costs Submission deadlines: Letter of intent due 29 April Applications due 20 May 52
53 FY10 NFRP New Investigator t Award Intent: Supports investigators t in the early stages of their careers Key Features: Experience in NF research is allowed by not required Preliminary data required Must be an independent investigator at or below the level of Assistant Professor with less that $300K in previous NF-related federal funding Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $400K in direct costs Submission deadlines: Letter of intent due 29 April Applications due 20 May 53
54 Intent: DOD Congressionally Directed Medical Research Programs FY10 NFRP Investigator-Initiated t I iti t Research haward Fund basic and clinically oriented research Investigator-Initiated Focused Research Award proposals must address one of these focus areas: Pain, wound repair, nerve regeneration, stress and inflammation, cognitive dysfunction, quality of life, neurofibromin protein Key Features: Preliminary data required Must be an independent investigator at or above Assistant Professor level Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $525K in direct costs, for collaborations that meet criteria specified in PA, $675K Submission deadlines: Letter of intent due 29 April Applications due 20 May 54
55 FY10 NFRP Clinical i l Trial Award Intent: Fund Phase 0, I, or II clinical trials Key Features: Preclinical data required Open to investigators at all academic levels Maximum period of performance is 4 years Maximum allowable funding for the entire period of performance is $900K in direct costs Submission deadlines: Letter of intent due 29 April Applications due 20 May 55
56 Tuberous Sclerosis Complex Research Program (TSCRP) Program Vision: To lessen the impact of TSC Congressional Appropriation FY $23.5M FY10 $6M 56
57 57 DOD Congressionally Directed Medical Research Programs FY10 TSCRP Career Transition Award Intent: Supports TSC researchers during the transition from postdoctoral training to an independent position Key Features: Funds the final 2 years of the postdoctoral position and the first 2 years of a faculty/independent position Preliminary data required Open to postdoctoral investigators with at least 2 years of postdoctoral experience Maximum period of performance is 4 years Maximum allowable funding for each postdoctoral year is $69K in direct costs Maximum allowable funding for each faculty-level year is $100K in direct costs Submission deadlines: Letter of intent due 29 April Applications due 20 May
58 Intent: FY10 TSCRP Exploration-Hypothesis th i Development taward Supports the initial exploration of innovative, untested research Key Features: Preliminary data encouraged but not required Open to investigators at all academic levels Human Subjects research must be exempt or qualified for expedited review Maximum period of performance is 2 years Maximum allowable funding for the entire period of performance is $100K in direct costs Submission deadlines: Letter of intent due 29 April Applications due 20 May 58
59 High Innovators Risk/High and Gain Leaders Research Additional Innovative CDMRP Research to Research Programs Leapfrog Advances 59
60 Autism Research Program (ARP) Program Vision: To improve the lives of individuals with autism spectrum disorders now Congressional Appropriation FY $21.9M FY10 $8M 60
61 61 DOD Congressionally Directed Medical Research Programs FY10 ARP Exploration-Hypothesis th i Development taward Intent: Supports initial exploration of innovative, untested questions or ideas Areas of Encouragement: Biological, infectious, or environmental risk factors Identifying therapeutic targets, excluding new gene discovery Key Features: Preliminary data not allowed Open to investigators at all academic levels Human subjects research must be exempt or eligible for expedited review Maximum period of performance is 2 years Maximum allowable funding for the entire period of performance is $100K in direct costs Submission deadlines: Letter of intent due 10 June Applications due 1 July
62 Genetic Studies of Food Allergies Research Program (GSFARP) Congressional Appropriation FY09 $2.5M FY10 $1.875M 62
63 FY10 GSFARP Concept taward Intent: Supports untested, high-risk questions relevant to the genetics of food allergies Key Features: Preliminary data not allowed Open to investigators at all academic levels Maximum period of performance is 1 year Maximum allowable funding for the entire period of performance is $75K in direct costs Submission i deadlines: dli Letter of intent due 27 May Applications due 10 June 63
64 Intent: FY10 GSFARP Idea Award Supports innovative ideas and potentially high-impact approaches Key Features: Preliminary data should be included Open to investigators at or above the level of Assistant Professor Maximum period of performance is 3 years Maximum allowable funding for the entire period of performance is $300K in direct costs Submission deadlines: Letter of intent due 27 May Applications due 10 June 64
65 Tips for Investigators Read the entire Program Announcement Contact for assistance Pay Particular Attention to: Award Description Eligibility and Funding Review Criteria peer and programmatic criteria Remember Abstracts are crucial! Public Abstract utilized by Programmatic Reviewers (who don t see the proposals) Review Summary Statement (resubmissions) 65
66 How to Apply CDMRP Mailing List Contact to be added to the list Pre-application (required) ereceipt CDMRP s pre-application pp submission system Application CFDA#
67 67
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