22 nd EDRN Steering Committee Meeting March 8-10, 2011 Covel Commons University of California, Los Angeles Los Angeles, California

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1 Monday, March 7, 2011 Agenda 4:00 6:30 p.m. Industry Forum (Hotel Palomar) Premiere Ballroom A&B Organizers: o Lynn Sorbara, Ph.D., National Cancer o Daniel Chan, Ph.D., Johns Hopkins o William Rom, M.D., M.P.H., New York o David Sidransky, M.D., Johns Hopkins School of Medicine Premiere Ballroom A&B Patient Advocates Social Event (following Industry Forum) Organizers: o Merel Grey Nissenberg, J.D., NASPCC/Mountain Foundation for Lung Cancer o o Elda Railey, Research Advocacy Network Carole Seigel, M.B.A., National Cancer

2 Tuesday, March 8, :00 8:00 a.m. Sign-In and Continental Breakfast Registration Desk/SV Terrace 8:00 8:05 a.m. Opening of Steering Committee Meeting Grand Horizon Ballroom Ian Thompson, M.D., of Texas Health Sciences Center at San Antonio 8:05 8:10 a.m. Welcome & Introduction Grand Horizon Ballroom Steven Dubinett, M.D., Professor and Chief, Division of Pulmonary and Critical Care Medicine Lung Cancer Research Program, Jonsson Comprehensive Cancer Center Associate Vice Chancellor for Research and Senior Associate Dean for Clinical and Translational Science, David Geffen School of Medicine at UCLA 8:10 8:20 a.m. Approval of September 2009 EDRN Steering Grand Horizon Ballroom Committee Minutes Ian Thompson, M.D., of Texas Health Sciences Center at San Antonio 8:20 8:50 a.m. State of the EDRN Grand Horizon Ballroom Sudhir Srivastava, Ph.D., M.P.H., National Cancer 8:50 9:30 a.m. Overview of the Jonsson Comprehensive Cancer Grand Horizon Ballroom Center Judith Gasson, Ph.D., Director, Jonsson Comprehensive Cancer Center, of California, Los Angeles 9:30 9:45 a.m. Break

3 Tuesday, March 8, 2011 Continued 9:45 10:15 a.m. Assessing EDRN Bioinformatics Needs for the Grand Horizon Ballroom Next Five Years o Sudhir Srivastava, Ph.D., M.P.H., National Cancer o Mark Thornquist, Ph.D., Fred Hutchison Cancer Research Center o Daniel Crichton, M.S., NASA Jet Propulsion Laboratory 10:15 a.m. 12:00 p.m. Session 1: Cancer Genome Sequencing Grand Horizon Ballroom Projects Chairs: o Mark Rubin, M.D., Weill Cornell Medical College o Jacob Kagan, Ph.D., National Cancer 10:15 10:35 a.m. Mark Rubin M.D., Weill Cornell Medical College 10:35 10:40 a.m. Q&A 10:40 11:00 a.m. Sandy Markowitz, Ph.D., Case Western Reserve 11:00 11:05 a.m. Q&A 11:05 11:25 a.m. Paul Spellman, Ph.D., The Cancer Genome Atlas/Lawrence Berkeley National Laboratory and National Cancer 11:25 11:30 a.m. Q&A 11:30 a.m. 12:00 p.m. Panel Discussion Panel Discussants: o Arul Chinnaiyan, M.D., Ph.D., of Michigan o Ann Killary, Ph.D., The of Texas MD Anderson Cancer Center o David Sidransky, M.D., Johns Hopkins School of Medicine o Avi Spira, M.D., Boston 12:00 1:30 p.m. Lunch (On Your Own)

4 Tuesday, March 8, 2011 Continued 1:30 3:20 p.m. Session 2: MicroRNAs and Early Detection Grand Horizon Ballroom Chairs: o Avi Spira, M.D., Boston o Wendy Wang, Ph.D., National Cancer 1:30 1:45 p.m. Muller Fabbri, M.D., The Ohio State Medical Center 1:45 1:50 p.m. Q&A 1:50 2:05 p.m. Subrata Sen, Ph.D., The of Texas MD Anderson Cancer Center 2:05 2:10 p.m. Q&A 2:10 2:25 p.m. Harvey Pass, M.D., New York 2:25 2:30 p.m. Q&A 2:30 2:45 p.m. Arul Chinnaiyan, M.D., Ph.D., of Michigan 2:45 2:50 p.m. Q&A 2:50 3:20 p.m. Panel Discussion Panel Discussants: o Surinder Batra, Ph.D., of Nebraska Medical Center o Marc Salit, Ph.D., National of Standards and Technology o Kai Wang, for System Biology o Avi Spira, M.D., Boston 3:20 3:35 p.m. Break 3:35 5:25 p.m. Session 3: Proteomics and Early Detection Grand Horizon Ballroom Chairs: o Dan Liebler, Ph.D., Vanderbilt Medical Center o Karl Krueger, Ph.D., National Cancer 3:35 3:50 p.m. Dan Liebler, Ph.D., Vanderbilt Medical Center 3:50 3:55 p.m. Q&A

5 Tuesday, March 8, 2011 Continued Session 3: Proteomics and Early Detection Continued Grand Horizon Ballroom 3:55 4:10 p.m. Paul Lampe, Ph.D., Fred Hutchinson Cancer Research Center 4:10 4:15 p.m. Q&A 4:15 4:30 p.m. Joshua LaBaer, M.D., Ph.D., Arizona State 4:30 4:35 p.m. Q&A 4:35 4:50 p.m. Hui Zhang, Ph.D., Johns Hopkins School of Medicine 4:50 4:55 p.m. Q&A 4:55 5:25 p.m. Panel Discussion Panel Discussants: o Dave Camp, Ph.D., Pacific Northwest National Laboratory o Steven Dubinett, M.D., o Samir Hanash, M.D., Ph.D., Fred Hutchinson Cancer Research Center o Pierre Massion, M.D., Vanderbilt/Ingram Cancer Center 5:25 7:30 p.m. Dinner (On Your Own) 7:30 9:30 p.m. Subcommittee Meetings (Hotel Palomar) (Closed Sessions-By Invitation Only) Premiere Ballroom A Directors Room Sundance Room Prioritization Subcommittee o EDRN PI TBD o Karl Krueger, Ph.D., National Cancer Technology and Resource Sharing Subcommittee o Karin Rodland, Ph.D., Pacific Northwest National Laboratory o Jacob Kagan, Ph.D., National Cancer Collaboration and Publication Subcommittee o Avi Spira, M.D., Boston o Lynn Sorbara, Ph.D., National Cancer

6 Tuesday, March 8, 2011 Continued Subcommittee Meetings (Closed Sessions-By Invitation Only)-Continued LA Film Room Communication and Workshop Subcommittee o Paul Engstrom, M.D., Fox Chase Cancer Center o Sanford Stass, M.D., of Maryland School of Medicine o Paul Wagner, Ph.D., National Cancer o Jo Ann Rinaudo, Ph.D., National Cancer Premiere Ballroom B Data Sharing and Informatics Subcommittee o Mark Thornquist, Ph.D., Fred Hutchinson Cancer Research Center o Christos Patriotis, Ph.D., National Cancer Wednesday, March 9, :00 8:00 a.m. Sign-In and Continental Breakfast Registration Desk/SV Terrace 8:00 a.m. 12:00 p.m. Collaborative Group Meetings (Closed Sessions-By Invitation Only) Salon BCD Breast and Gynecological Cancers Salon A Gastrointestinal Cancers Salon EFG Lung and Other Upper Aerodigestive Cancers South Bay Prostate and Other Urological Cancers 10:00 10:20 a.m. Break 12:00 1:30 p.m. Lunch (On Your Own) 12:00 1:30 p.m. EDRN EC Meeting (Closed Session--By Salon A Invitation Only)

7 Wednesday, March 9, 2011 Continued 1:30 3:30 p.m. Collaborative Group Meetings (Closed Sessions-By Invitation Only) Issues to address: 1. Solutions to problems identified in morning session 2. How to move forward 3. Score card for marker to successfully go forward 3:30 3:45 p.m. Break 3:45 5:45 p.m. Interest Group Meetings South Bay Proteomics Chair: Jacob Kagan, Ph.D., National Cancer Salon EFG Imaging Chair: Richard Mazurchuk, Ph.D., National Cancer Salon BCD Genomics Chairs: Christos Patriotis, Ph.D., and Wendy Wang, Ph.D., National Cancer Thursday, March 10, :00 8:00 a.m. Sign-In and Continental Breakfast Registration Desk/ 8:00 8:30 a.m. Outcome of MSA Validation Trial for Bladder Cancer Mark Schoenberg, M.D., Johns Hopkins 8:30 10:00 a.m. Team Projects Updates (15 minutes each) Prostate o Breast o Ovarian o Lung o Pancreas o Colon

8 Thursday, March 10, 2011 Continued 10:00 10:20 a.m. Break 10:20 11:05 a.m. Reports from Interest Groups (15 minutes each) Genomics o Proteomics o Imaging 11:05 11:55 a.m. Reports from Subcommittees (10 minutes each) Prioritization Subcommittee o Technology and Resource Sharing Subcommittee o Communication and Workshop Subcommittee o Collaboration and Publication Subcommittee o Data Sharing and Informatics Subcommittee 11:55 a.m. 12:00 p.m. Final Remarks Ian Thompson, M.D., of Texas Health Sciences Center at San Antonio o Sudhir Srivastava, Ph.D., M.P.H., National Cancer 12:00 p.m. Adjourn