Welcome to OPEN DOORS

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1 Welcome to OPEN DOORS A support program for IPF patients taking OFEV (nintedanib) capsules For more information, call OPEN DOORS at OPENDOOR ( ), or visit IPF=idiopathic pulmonary fibrosis. Please see throughout this brochure and accompanying Patient Information, provided

2 The OPEN DOORS Patient Support Program At OPEN DOORS, we understand how overwhelming it can be to learn you have idiopathic pulmonary fibrosis, or IPF. We re here to help answer your questions about IPF and OFEV (nintedanib) so you can focus on your health. Financial guidance We can assist you in exploring options that may partially cover the costs of your OFEV capsules. You may be able to get OFEV for $0 through one of the following options: Prescription copay support for commercially insured patients Alternate sources of funding for eligible patients with noncommercial pharmacy benefits The BI Cares Patient Assistance Program for eligible patients with limited or no health insurance What is OFEV? OFEV is a prescription medicine used to treat people with a lung disease called idiopathic pulmonary fibrosis (IPF). It is not known if OFEV is safe and effective in children. What is the most important information I should know about OFEV (nintedanib)? OFEV can cause harm, birth defects or death to an unborn baby. Women should not become pregnant while taking OFEV. Women who are able to become pregnant should have a pregnancy test before starting treatment and should use birth control during and for at least 3 months after your last dose. If you become pregnant while taking OFEV, tell your doctor right away. 2 Please see additional throughout

3 More OPEN DOORS benefits You and your caregiver can also rely on OPEN DOORS to: Connect you with a nurse by phone at any time of the day or night Answer questions about how the Specialty Pharmacy works and the phone calls you will receive from them Identify social resources in your area such as transportation, home care, meals, and support groups To enroll in OPEN DOORS, fill out and sign the enclosed form and mail it in the envelope provided, or fax it to OFEV ( ) What should I tell my doctor before using OFEV? Before you take OFEV, tell your doctor if you have: liver problems heart problems a history of blood clots a bleeding problem or a family history of a bleeding problem had recent surgery in your stomach (abdominal) area any other medical conditions. 4 What should I tell my doctor before using OFEV? (cont d) Tell your doctor if you: are pregnant or plan to become pregnant. are breastfeeding or plan to breastfeed. It is not known if OFEV passes into your breast milk. You should not breastfeed while taking OFEV. are a smoker. You should stop smoking prior to taking OFEV and avoid smoking during treatment. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements such as St. John s wort. Please see additional throughout

4 Speak with a Clinical Educator When you know what you re dealing with, you can feel more prepared to face the challenge. That s why OPEN DOORS helps schedule a class for you with a Boehringer Ingelheim Clinical Educator. Clinical Educators are skilled and compassionate medical professionals who can help you better understand IPF, its impact on you and your family, and your treatment with OFEV (nintedanib). Your caregiver and family members are also welcome to attend this informative class. The Clinical Educator will personalize the conversation based on the information you want and need. They can help you learn more about: IPF and what happens as it progresses Getting started on OFEV capsules How OFEV works and what you can expect from treatment Continuing use of OFEV as prescribed To schedule a class with a Clinical Educator, call OPEN DOORS at OPENDOOR ( ). Your doctor s office can also set up a class on your behalf What are the possible side effects of OFEV? OFEV may cause serious side effects. TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: Liver problems. Unexplained symptoms may include yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal or feeling tired. Your doctor will do blood tests regularly to check how well your liver is working during your treatment with OFEV. Diarrhea, nausea, and vomiting. Your doctor may recommend that you drink fluids or take medicine to treat these side effects. Tell your doctor if you have these symptoms, if they do not go away, or get worse and if you are taking over-the-counter laxatives, stool softeners, and other medicines or dietary supplements. 6 Please see additional throughout

5 Circle of support Patient education Comprehensive Clinical Educator session Disease state and treatment resources Patient education Emotional support Monthly nurse check-in Nurse on-call 24/7 Social workers Financial guidance Emotional support Day-to-day assistance Home care Meal delivery Transportation to medical visits Local support groups Coordination of paperwork Day-to-day assistance Financial guidance Explanation of pharmacy benefits Financial assistance options 8 Please see additional throughout

6 OPEN DOORS is here to help support you whether you re just beginning treatment with OFEV (nintedanib) capsules or have been taking them for a while. To enroll in OPEN DOORS : Fill out and sign the enclosed form Mail it in the envelope provided or fax it to OFEV ( ) For more information, call OPEN DOORS at OPENDOOR ( ), or visit What are the possible side effects of OFEV? (cont d) TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: Heart attack. Symptoms of a heart problem may include chest pain or pressure, pain in your arms, back, neck or jaw, or shortness of breath. Stroke. Symptoms of a stroke may include numbness or weakness on 1 side of your body, trouble talking, headache, or dizziness. Bleeding problems. OFEV may increase your chances of having bleeding problems. Tell your doctor if you have unusual bleeding, bruising, or wounds that do not heal and/or if you are taking a blood thinner, including prescription blood thinners and over-the-counter aspirin. What are the possible side effects of OFEV? (cont d) TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: Tear in your stomach or intestinal wall (perforation). OFEV may increase your chances of having a tear in your stomach or intestinal wall. Tell your doctor if you have pain or swelling in your stomach area. The most common side effects of OFEV are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure. These are not all the possible side effects of OFEV. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit medwatch or call FDA Please see accompanying Patient Information provided

7 Get the support you need today For more information, call OPEN DOORS at OPENDOOR ( ), or visit Please see throughout this brochure and accompanying Patient Information, provided in the pocket of this brochure. Copyright 2016, Boehringer Ingelheim Pharmaceuticals, Inc. All rights reserved. (12/16) PC-OF-0416-CONS

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