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1 Early Identification and Treatment of Sepsis (Non Red Flag, Red Flag and Septic Shock) Type: Clinical Guideline Register No: Status: Public Developed in response to: Clinical need Contributes to CQC Outcome number: 4 Consulted With Post/Committee/Group Date Dr Louise Teare DIPC 23/2/17 Dr James Orpin Deteriorating Patient Group 23/2/17 Dr Natasha Lawrence Deteriorating Patient Group 23/2/17 Zaheera Hassanali Lead Pharmacist - Antimicrobials 23/2/17 Professionally Approved By Dr Robert Ghosh Clinical Effectiveness Dr Kath Rowe Medical Director 23/2/17 17 July 2017 Version Number 2.0 Issuing Directorate Diagnostics Ratified by: Ratified on: 9 th August 2017 Executive Management Board Sign Off Date September 2017 Implementation Date 30 th August 2017 Next Review Date July 2020 Author/Contact for Information Policy to be followed by (target staff) Distribution Method Related Trust Policies (to be read in conjunction with) Document Ratification Group Chairman s Action Dr Evans/C Bishop Clinical Staff Intranet and website Antibiotic Policy Trigger Response Team Operational Policy Document Review History Version Brief Reason for Change or Number Update Reviewed Authored or Reviewed by Active Date 1.0 First version Dr Hieatt, R Teare 13th November Update to Appendix 4 Carole Bishop 26 th January Update to Appendix 4 and Dr Lightfoot, C Bishop 29 th May 2015 removal of Appendix Amendment to wording of 4.8 Maria Richards Nov 2015 approved by Dr Davis 2.0 Full Review Carole Bishop 30 August
2 INDEX 1. Purpose 2. Scope 3. Introduction 4. Roles and Responsibilities 5. Definition/Recognition of Sepsis 6. Management of Sepsis 7. Staff Training and Communication 8. Audit & Monitoring 9. References Appendix 1: Appendix 2: Flow Diagram Explaining Use of Documents / Process Sepsis Screening and Action Tool 2
3 1. Purpose 1.1 To ensure that effective care and a timely response is achieved in the management of sepsis in adults. 2. Scope 2.1 These guidelines set out the principles of early identification and treatment of sepsis (Non Red Flag, Red Flag and Septic Shock) in Adults. This guideline does not apply to sepsis in the Paediatric or Maternity setting as these are subject to separate guidelines, Management of Sepsis 0-16 yrs. and Post Partum Sepsis. For patients on chemotherapy with neutropenic sepsis follow the neutropenic sepsis protocol. 2.2 These guidelines are for the use of all nursing and medical staff within Mid Essex Hospitals NHS Trust. 3. Introduction 3.1 Early appropriate management saves lives. Delay costs lives. Mortality increases by 8%/hr and 5%/hr respectively for septic shock and sepsis if left untreated with appropriate antibiotics. This is true for the first 6hrs after the patient develops sepsis. 3.2 Recognition of sepsis and septic shock must be at the front door by nursing staff performing triage, pre-hospital by paramedics, on the wards by nursing staff doing observations and by attending medical staff. 4. Roles and Responsibilities 4.1 Chief Executive: To ensure that an effective policy is in place and working. 4.2 All medical and nursing staff has a responsibility to ensure they understand this policy and act on its contents in an appropriate way. 4.3 Triage Nurses in the Emergency Village: Use sepsis screening tool on all patients that have a single NEWS of 3 or more when first seen and initiate indicated actions. If sepsis occurs on a ward nurse/health care assistant to complete observations and escalate as appropriate. 4.4 Emergency Village Doctors: All patients that trigger for Sepsis should be assessed, appropriate treatments prescribed and administered within 60 minutes of triggering for Sepsis as per protocol. Prescribe antibiotics in accordance with protocol and likely source of sepsis. Check venous blood gas result and check that appropriate IV antibiotics have been delivered within an hour of patient triggering sepsis positive. Ensure timely administration of oxygen and IV fluid. Contact senior for review as appropriate. Ensure understanding that all patients triggering sepsis positive must have a senior review by a ST3 or above before leaving the Emergency Village and / or within 1 hour. 4.5 Heads of Nursing and Clinical Directors: Take responsibility to ensure their staff have knowledge and competencies aligned to their roles and responsibilities. 3
4 4.6 Emergency Village ST3: Respond promptly to sepsis patients being escalated to them and ensure patients are monitored appropriately for any signs of deterioration. Escalate patients appropriately to specialist teams and consultants and consider if critical care referral is required and appropriate for consideration of specific organ support. 4.7 Speciality Consultants: Review the patient and consider if referral to the Critical Care Consultant is required and appropriate for organ support. 4.8 Pharmacists: Stocking the sepsis trolleys in the emergency department with appropriate antibiotics. 5.0 Definition of Sepsis: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. This emphasizes the primacy of the nonhomeostatic host response to infection, the potential lethality that is considerably in excess of a straightforward infection, and the need for urgent recognition. Even a modest degree of organ dysfunction when infection is first suspected is associated with in-hospital mortality in excess of 10%. Therefore, recognition of this condition merits a prompt and appropriate response. 5.1 Recognition of Sepsis: Diagnosis of Sepsis has three categories which are determined in ascending order of severity Non Red Flag Sepsis, Red Flag Sepsis and Septic Shock. Each category (Non Red Flag, Red Flag or Septic Shock) must be clearly documented in the patient s notes with date and time This Trust utilises National Early Warning Scores to identify deteriorating patients, therefore, Quick sequential organ failure assessment (qsofa) is not endorsed outside of critical care. However, patients that meet two or more of the following qsofa criteria are at risk of deteriorating: Respiratory Rate of >22 breaths per minute Systolic Blood Pressure < 100 mmhg GCS 13 Patients meeting any two of the above parameters should be reviewed using the Sepsis Screening and Action Tool (Appendix 2) to ensure they do not have organ failure and appropriate management is instigated. 5.2 Non Red Flag Sepsis: The patient has an aggregated NEWS of 4 or more/looks unwell? And There is a possible source of infection (confirmed or suspected) And ANY moderate risk criteria (Non Red Flag Criteria): Altered mentation/acute loss of functional ability 4
5 Relatives concerned about mental status Immunosuppressed Trauma/surgery in last 6 weeks Respiratory Rate (RR) breaths per minute Heart Rate (HR) beats per minute Systolic BP mmhg Not passed urine in the last 18 hours Temperature < 36 o C Clinical signs of wound, device or skin infection 5.3 Red Flag Sepsis: The patient has a single NEWS of 3 or more/looks unwell? And There is a possible source of infection (confirmed or suspected) And ANY one red flag is present: Systolic BP 90 mmhg (or drop >40 from normal) Lactate 2 mmol/l Red NEWS for Respiratory Rate (RR) 25 breaths per minute Red NEWS for Heart Rate (HR) 130 beats per minute Red NEWS for conscious level GCS 13 or V on AVPU Scale Needs oxygen to keep SpO 2 92% (88% in COPD) Non-blanching rash, mottled/ ashen/ cyanotic Oliguria (from history or less than 0.5 ml/kg/hr) Recent chemotherapy (within last 6 weeks) 5.4 Further clinical considerations: New onset Atrial Fibrillation (AF) or poorly rate controlled existing AF Jaundice Bilirubin > 34 umol/l or abnormal LFTs Coagulation abnormalities INR > 1.5 and low platelets < 100 Low WBC 12 x 10 9 /l or 4 x 10 9 /l Neutrophils <0.5 (for patients having had recent chemotherapy) Metabolic acidosis Creatinine > 177 umol/l or 50% > than baseline 5.5 Septic Shock As above + refractory hypotension AND persistently raised lactate (>2mmol/l) despite 30 mls/kg volume resuscitation with Hartmann s Solution or Normal Saline Hypotension is defined as systolic blood pressure (SBP) of less than 90mmHg or diastolic blood pressure (DBP) of less than 60mmHg in a fit healthy individual. In the elderly and hypertensive, it is defined as a SBP drop >40 mmhg or a DBP drop of 20mmHg below the patients normal resting blood pressure. 110/60 is a normal BP for a healthy 20 year old. It is not normal for a healthy 70 year old. 5
6 5.5.3 A useful guide for predicted normal SBP is 90+2/3 patient age in years. To predict normal DBP, add 50 to ½ patient age in years. Normal blood pressure does not always equate to normal organ perfusion and oxygen delivery or utilisation. Mean Arterial Pressure (MAP) may be acceptable yet poor perfusion could be on-going despite 30 mls/kg volume resuscitation. A persistently raised serum lactate >2 mmol/l that does not resolve requires a search for and treatment of shock with input from critical care as appropriate. 6.0 Management of Sepsis 6.1 Early appropriate management saves lives. Delay costs lives. Mortality increases by 8% per hour for septic shock and 5% per hour for sepsis if not treated with appropriate antibiotics. This is true for the first 6 hours after the patient triggers. The mortality for septic shock is already high at between 25 and 40%. A patient with septic shock left untreated with appropriate antibiotics for 6 hours has a 48% higher mortality compared to one treated appropriately within the first hour of admission. Do the simple things well in a timely fashion. 6.2 Sepsis Six Bundle: College of Emergency Medicine Standard In Red Flag Sepsis and Septic Shock, the first five points must be achieved within the first 60 minutes of admission to the Emergency Village or recognition on the ward. The 6th point must be achieved before 3hrs. Use the Sepsis Six Action Tool in the Emergency Village Booklets or place in the patient s notes. 1. High flow oxygen 2. Blood cultures before antibiotics 3. Measure venous lactate and venous blood gas (VBG) 4. Appropriate IV antibiotics as per trust protocol mls/kg volume resuscitation with Hartmann s solution over 30 minutes 6. Catheter and hourly urine measurement Staff must ensure prescription and delivery of appropriate IV antibiotics after taking blood cultures, as soon as the patient triggers as sepsis positive. An appropriate doctor must be diverted urgently for rapid assessment of likely source to guide therapy. It is the responsibility of nursing staff to escalate and the doctor s responsibility to assess the patient within 10 minutes of being asked, prescribe the antibiotics and ensure they have been given. Nursing staff are responsible for drawing up the antibiotics and giving them within 10 minutes of them being prescribed. Sepsis PGD s are in place for band 6/7 nursing staff that have completed appropriate competencies Refractory hypotension despite 30 ml/kg fluid resuscitation mandates careful reassessment by the ED or speciality ST/consultant and on-going management may require central venous (CVP) line-guided filling and measurement of central venous oxygen saturation (ScvO2) if appropriate. However, the patient s fluid responsiveness and volume status may be better assessed by ultrasound (USS) assessment of inferior vena cava (IVC) collapse and/or right ventricular distension if the assessing doctor has appropriate training. Central venous access will enable delivery of norepinephrine by infusion should the patient remain persistently hypotensive despite optimum filling. The sepsis six action plan must be completed and, where appropriate, be placed in the patient s notes. 6
7 6.2.4 All patients with Red Flag Sepsis and Septic Shock require senior review and appropriate observation frequency determined for individual patients. Consideration of appropriateness of referral for management in a high-dependency environment and must be discussed with the speciality consultant on-call and documented. Failure to respond to the sepsis 6 treatment should prompt early speciality senior review and consideration of referral to critical care unit for organ support if appropriate. 7. Staff Training and Communication 7.1 All medical and nursing staff to ensure that their knowledge, competencies and skills are up to date and in line with roles and responsibilities outlined above. During the induction process, all junior medical and nursing staff will receive instruction on current sepsis policies and guidelines. 7.2 Medical and nursing staff will be kept up to date with teaching, ongoing case presentations discussing severe sepsis and learning from outcomes. 7.3 Ongoing discussion as necessary will take place at all relevant operational and directorate meetings. 7.4 Sepsis PGD training to be undertaken prior to applying them in practice. 7.5 This policy will be communicated with all staff by and discussed at relevant sisters meetings. Discussion will also take place at all relevant directorate and operational team meetings. 8. Audit & Monitoring 8.1 Where failure to follow this guidance compromises patient safety, the incident will be reported via the Trust s risk event reporting system. Reported incidents will be reviewed quarterly as a minimum by the Deteriorating Patient Group. Go to the Failure to Rescue Tab on the Trust Intranet home page. 8.2 Any breaches of protocol leading to harm will be reviewed by the Deteriorating Patient Group and outcomes actioned appropriately by directorate and operational teams. 8.3 The Deteriorating Patient Group will identify any issue requiring the attention of the Patient Safety Group. 8.4 Any sepsis related deaths will be reviewed by the Mortality Group to ensure appropriate standards of care were met and key findings reported to the Patient Safety Group and the Patient Safety and Quality Committee as appropriate. 8.5 Regular audits of the sepsis pathway will be undertaken by the Trust to ensure standards are being met and reported via the Deteriorating Patient Group to the Patient Safety and Quality Committee. 7
8 9.0 References Dellinger RP, Levy MM, Carlet JM, et al. (January 2008). Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: Intensive Care Med 34 (1): doi: /s PMC PMID Singer,M, Clifford S D, Seymour W D, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard G R, Chiche J-D, Coopersmith C M, Hotchkiss R S, Levy M M, Marshall J C, Martin G S, Opal S M, Rubenfeld GD, Poll T, Vincent J L, and Angus D C (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016;315 (8):
9 Appendix 1 Flow Diagram Explaining Use of Documents / Process The Sepsis and Septic Shock Screening and Action Tool: for reference by all medical and nursing staff. SEPSIS SCREENING TOOL (SERT) APPLIED TO ALL MAJORS PATIENTS AND AMBULANCE ARRIVALS IN THE ED, MAU, ANYONE SUSPECTED OF HAVING SEPSIS OR NEWS OF >3 IN AN INPATIENT SETTING IF SEPSIS SCREEN POSITIVE THE SEPSIS 6 ACTION PLAN IS COMPLETED AND BUNDLE DELIVERED WITHIN AN HOUR THE PATIENT IS MOVED TO AN AREA WHERE APPROPRIATE MONITORING CAN TAKE PLACE APPROPRIATE SENIOR REVIEW BY CT/ ST / CONSULTANT AFTER FLUID BOLUS DELIVERED AND REPEAT LACTATE ON VBG THIS SHOULD BE WITHIN 1 HOUR OF TRIGGERING FOR SEPSIS IF RESUSCITATION GOALS ARE NOT ACHIEVED AFTER SENIOR REVIEW THEN ESCALATED TO SPECIALITY CONSULTANT SPECIALITY CONSULTANT MUST REVIEW THE PATIENT AND ESCALATE TO THE INTENSIVE CARE CONSULTANT ON CALL IF APPRIOPRIATE 9
10 Appendix 2 10
11 11
Modified Early Warning Score Policy.
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