PRimary care Opioid Use Disorder (PROUD) Trial. CSAT NIDA CTN Webinar October 19 th, 2016
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1 PRimary care Opioid Use Disorder (PROUD) Trial CSAT NIDA CTN Webinar October 19 th, 2016 Kathy Bradley, MD, MPH Senior Investigator, Group Health Research Institute Affiliate Professor Medicine and Health Services, University of Washington Research Associate VA Puget Sound HSR&D 1
2 Overview The PROUD Trial Increasing Access to High Quality Medication Treatment for OUD in Primary Care 2
3 PROUD Trial Design Protocol Development Betty Tai John Rush Andy Saxon Denise Boudreau Jeffrey Samet Cynthia Campbell Gwen Lapham Jennifer Bobb Gavin Bart Robert Schwartz Coleen Labelle Jennifer McNeely Jane Leibschutz Abby Wright Jennifer Bobb Jennifer McCormack Zoe Weinstein Joe Merrill Judy Tsui Allison Lin
4 Overview My Presentation 1. Background 2. Design of the PROUD Trial 3. PROUD Phase 1
5 Part 1 Background 5
6 Background Opioid epidemic Need to increase treatment for OUD Effective medications for OUDs Methadone Buprenorphine Injectable naltrexone Persistence for 12 mo. improves outcomes Mattick Cochrane Database 2008, Lo-ciganic, Addiction 2016
7 Background Gaps in care 85% no treatment Only 15% receive treatment ~ 21% still on meds at 12 months ~ 3% receive persistent treatment Becker DAD 2008; Lo-ciganic, Addiction 2016
8 Background High quality OUD treatment will 1. Attracts those with OUDs into treatment 2. Treats OUDs with medications 3. Keep patients on medications 12 mo. 4. Improves health outcomes
9 Background Barriers 1. Stigma keeps people with OUDs hidden 2. Barriers to buprenorphine prescribing Time Complexity 3. Health Systems believe current treatment is adequate no one is asking for more!
10 Background Efforts to date: Education-based: buprenorphine Increase waivered MDs Most do not prescribe Low rates of persistence at 12 months (21%) Implementation strategies for primary care (PC) Collaborative care Massachusetts model 11 other models AHRQ 2016; Becker DAD 2008
11 Massachusetts (MA) Model 11
12 Massachusetts (MA) Model Components Nurse care manager: 100 patients Nurse does all but diagnose & prescribe MDs: diagnosis and prescribe Technical assistance/training Public reporting Alford Arch Intern Med 2011; LaBelle JSAT 2016; Clark Health Affairs 2015
13 Massachusetts Model Effects to Date 70-93% of patients NEW Build it and they will come Most evidence Only model with high rates of persistence 50-67% engaged at 12 months Mostly public financing and FQHCs 53% of people with OUDs: private insurance Alford Arch Intern Med 2011; LaBelle JSAT 2016; Clark Health Affairs 2015
14 Part 2 The PROUD Trial A cluster randomized, pragmatic comparative effectiveness trial of Massachusetts Model vs Usual Primary Care 14
15 PROUD Trial Research Question Does the MA Model when compared to Usual PC increase the number of days of medication treatment for OUDs per 10,000 patients at least 2 fold?
16 PROUD Trial Secondary Aims 1. Does the MA Model when compared to Usual PC increase the proportion of primary care patients who: a. Are diagnosed with OUDs? b. Receive medications for OUDs? c. Receive high quality OUD treatment Persistent for12 months?
17 PROUD Trial Secondary Aims (continued) 2. Does the MA Model when compared to Usual PC decrease the proportion of PC patients with OUDs who use acute care services in the following year? Urgent care Emergency department care Hospital care
18 Overview of PROUD Design Hybrid Type II Effectiveness-implementation trial Pragmatic cluster randomized ( ) trial Setting: large health care systems Data all secondary EHRs sample, diagnoses, medications Claims data: pharmacy, ICDs, utilization Death data (later)
19 Overview of PROUD Design Data all secondary EHRs sample, diagnoses, medications Claims data: pharmacy, ICDs, utilization Death data (later) Waivers Informed consent HIPAA waiver 42CFR does not apply: data de-identified Dates & zip codes not identifiers in 42CFR
20 Overview of PROUD Design Six health care (HC) systems 2 primary care clinics each (12 total) > 10, 000 patients each Stratified randomization (within HC system)
21 Overview of PROUD Design ~ 6 Health Care Systems 2 Primary care clinics each MA Model Usual PC 6 PC clinics 6 PC clinics >60,000 pts >60,000 pts > 540 w/oud >540 w/oud
22 PROUD Trial: Implementing the MA Model NIDA funds RN care manager HC system implements MA model Study provides technical assistance
23 Overview of PROUD Design Primary sample: All patients who visit the PC clinics in the 6-18 months after randomization
24 Overview of PROUD Design Primary outcome # days OUD medication treatment/10,000 pts Secondary outcomes OUD diagnoses OUD treatment Persistent treatment 12 months Acute care
25 PROUD Timeline Overview Trial starts here
26 PROUD Timeline Overview Trial starts here Look back: 24 mo. covariates
27 PROUD Timeline Overview Trial starts here Look back: Outcomes 24 mos. EHR/claims data covariates 6mo. RN hired & trained 12 mo. Start OUD medications 12 mo. Follow-up
28 PROUD Innovations Pragmatic implementation trial Sample generalizable Diverse health systems All data from EHRs
29 PROUD Innovations Primary outcome reflects both: Access (# of patients treated) Quality (persistence of treatment) Secondary outcome, persistent OUD treatment: predicts health outcomes Evaluate OUD in insured population
30 Secondary Grants? 1. What are the barriers and facilitators to improving outcomes with the MA model in large integrated health care systems or health insurance plans 2. Cost-effectiveness of MA model or the business case for payers
31 Part 3 PROUD Phase 1 Preparing for the Trial 31
32 PROUD Phase 1 Goals Demonstrate ability to extract data on: Sample Outcomes Covariates Obtain data for Statistical power simulations Selecting clinics Understand barriers and facilitators Identify and engage willing HCs
33 Participating Healthcare Systems PROUD Phase 1 Healthcare Systems Group Health (lead site) Kaiser Permanente Northwest Harris Health System Kaiser Permanente S. California HealthPartners Henry Ford Health System Kaiser Permanente Colorado Montefiore MultiCare Health System U Miami Health System Kaiser Permanente N. California 33
34 Phase 1 Summer 2016 Phase 1 Protocol 11 HC systems selected Group Health IRB other sites cede Data Sharing Agreement drafted Data specifications
35 Phase 1 Fall 2016 Seattle Subcontracts with 11 sites Data extraction and programming Design Phase 2 implementation Engage sites weekly meetings Bi-weekly meetings support sites Two sets: programmers and site PIs/PMs
36 Phase 1 Winter 2017 Data collection and analyses Letters of support Select sites
37 Phase 1 Spring 2017 Engage health care systems for trial IRB for trial DUAs for trial Subcontracts done Randomization early summer
38 Conclusion Innovative pragmatic trial Evaluate the MA model Increase access & quality? Rapid launch Designed April launched September Phase 1 selects 6 HC systems Phase 2 starts June
39 Thank You! 39
40 Questions? Comments? Discussion? 40
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