Surgical Legacies of Modern Combat: Translating Battlefield Medical Practices into Civilian Trauma Care
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1 American College of Surgeons All rights reserved Worldwide. Surgical Legacies of Modern Combat: Translating Battlefield Medical Practices into Civilian Trauma Care Achieving Zero Preventa bl e Deaths Conferenc e April 18-19, 2017 B r i a n E a s t r i d g e, M D, F A C S C O L, M C, U S A R P r o f e s s o r o f S u r g e r y U n i v e r s i t y o f T e x a s H e a l t h S a n A n t o n i o
2 Disclosures None Disclaimer The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
3 War s Role as a Teacher For Antiquity He who would become a surgeon should join an army and follow it for war is the only proper school for a surgeon..
4 World War I IV fluids Blood transfusions Motorized ambulances Topical antisepsis History of Battlefield Medical Lessons Korean Conflict Improved fluid resuscitation Forward availability of definitive surgery Helicopters for patient evac/transport Primary repair/grafts for vascular injury World War II Whole blood/plasma available Specialty-specific surgical groups Antibiotics Fixed wing aero-medical evacuation Desert Shield/Storm Burn team augmentation of evacuation hospitals to provide theater-wide burn care Intercontinental aeromedical Vietnam transport of burn patients Improved use of helicopters Improved laboratory support Portable radiology equipment Mechanical ventilators in theater
5 Contemporary Battlefield Lessons Learned Joint Trauma System Focused empiricism / timely dissemination of knowledge Performance Improvement / generation of best practices Epidemiology of injury death Tactical Combat Casualty Care Acute surgical care Damage control resuscitation Forward surgical elements Serial damage control surgery
6 Genesis of the Military Trauma System Effort Review of Battlefield Medical Care Army Trauma Consultant 2003 Unorganized delivery of trauma care on the battlefield Casualties going to the wrong location Suboptimal staffing and placement of surgical assets Medical records are not reliably being delivered with casualties at each level (<40%) Impact on clinical care Documentation directive No trauma registry driven by medical input that allows accurate description of injuries or deaths Unable to reliably answer questions and improve outcomes Survivable Injuries and/or deaths Lack of performance improvement measures / research
7 American College of Surgeons All rights reserved Worldwide. Battlefield Lesson Learning Healthcare System
8 Joint Trauma System Operational Cycle TRAUMA CARE DELIVERY PERFORMANCE IMPROVEMENT DATA ANALYSIS DOD TRAUMA REGISTRY FIGURE 4-3 Joint Trauma System operational cycle and links to the U.S. Department of Defense s Combat Casualty Care Research Program. NOTE: DoD = U.S. Department of Defense; PI = performance improvement. SOURCE: Haut et al., 2016.
9 JTS Directorate Functions and Services Performance Improvement Reports Clinical Practice Guidelines Concurrent Reports Special Projects
10 Clinical Practice Guidelines Evidence-based Best clinical practice Tailored to operational battlefield environment Open access Resource for deploying surgeons and medical providers
11 Focused Epiricism Pragmatic approach to process improvement Urgency to improve outcomes because of high morbidity and mortality rates High-quality data are not available to inform clinical practice changes Data collection is possible. Principle of focused empiricism is using the best data available in combination with clinical experience to develop clinical practice guidelines through an iterative process Successes Damage control resuscitation Whole blood for massive transfusion Tranexamic acid Failures Factor VIIa
12 Avg Number of Units Average Component Units per Massive Transfusion Deployment of 1st JTTS trauma team Aug 2004 Official Massive Transfusion CPG issued Dec PRBC FFP 10 Whole Blood Platelets Year
13 Damage Control Resuscitation Compliance 70.0% 60.0% IRAQ AFGHANISTAN 50.0% 40.0% 30.0% Crude Adherence Rate Death Rate 20.0% 10.0% 0.0%
14 American College of Surgeons All rights reserved Worldwide. Battlefield Lesson Epidemiology of Prehospital Trauma Mortality
15 DOW KIA
16
17 Hemorrhage Focus (n=888) 13.5% n=119 Truncal Junctional 19.2% n= % n=598 Extremity 39% Cervical (max AIS 1) 61% Axilla and Groin (max AIS 5) 36% Thoracic (max AIS 3) 64% Abdominopelvic (max AIS 4/5)
18 Eliminating Preventable Death on the Battlefield US Military Preventable Prehospital Deaths = 25% US Rangers Preventable Deaths = 3% Ranger success attribution: Leadership Command-directed casualty response program Training All Rangers and Docs trained in TCCC Kotwal RS, Montgomery HR, Kotwal BM, et al. Eliminating preventable death on the battlefield. Arch Surg 2011.
19 Multi-Disciplinary Multi-Institutional Mortality Investigation in the Civilian Prehospital Environment (MIMIC) Develop a methodology for evaluating the causes and pathophysiology of pre-hospital deaths (optimal & in context) Network of experts to apply the methodology to identify the causes of pre-hospital deaths due to trauma and estimate the potential for survivability. Trauma surgery Neurosurgery Orthopedic surgery Forensic pathology Emergency medicine Emergency medical services
20 Multi-Disciplinary Multi-Institutional Mortality Investigation in the Civilian Prehospital Environment (MIMIC) Define the causes and pathophysiologic mechanisms of 3,000 pre-hospital deaths occurring in six regions of the country representative of the population. Describe the epidemiology of pre-hospital mortality in the context of trauma system development and estimate human and fiscal impact on society. Develop a blueprint for a sustained public health / injury mitigation strategies in the pre-hospital environment, identifying high priority areas for trauma systems performance improvement
21 American College of Surgeons All rights reserved Worldwide. Battlefield Lesson Pre-Hospital Care
22 Tactical Combat Casualty Care Tactical Combat Casualty Care Set of trauma management guidelines customized for the battlefield that focus on the most common causes of preventable deaths on the battlefield: Hemorrhage Noncompressible Junctional Peripheral Airway obstruction Tension pneumothorax Butler FK, Hagmann J, Butler EG. Tactical combat casualty care in special operations. Military Medicine 1996;161(Suppl.):3-16.
23 Pre-Hospital Translation of Lessons Learned Tactical Combat Casualty Care Hartford Consensus Threat suppression Hemorrhage control Rapid Extrication to safety Assessment by medical providers Transport to definitive care Need integrated response Fire, EMS, Law Enforcement, Medical
24 The Hartford Consensus American College of Surgeons FBI White House Medical Policy White House Medical Asst Secretary of Defense - Health Affairs Asst Secretary of Homeland Security Health Affairs Medical Section Major Chiefs of Police ACS Committee on Trauma DoD Committee on TCCC Improving Survival from Active Shooter Events: The Hartford Consensus Active Shooter and Intentional Mass-Casualty Events: The Hartford Consensus II The Hartford Consensus III: Implementation of Bleeding Control The Hartford Consensus IV: A Call for Increased National Resilience 24
25 Pre-Hospital Translation Initiatives LEFR-TCC Law Enforcement First Responder Tactical Casualty Care NAEMT
26 Hemorrhage Control: Tourniquets Kragh, et al Tourniquet Study Ibn Sina Hospital, Baghdad, 2006 Tourniquets are saving lives on the battlefield 31 lives saved in 6 months by use of prehospital tourniquets Kragh JF, Walters TJ, Baer DG, et al. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Annals of Surgery, (1):1-7.
27 Impact of Tourniquets on the Battlefield Isolated Extremity Deaths / Year Pre- Tourniquet (Pre 2006) Transi on ( ) Post-Tourniquet (Post 2007) TCCC Interven on Eastridge et al: Death on the Battlefield: Implications for the Future of Combat Casualty Care. J Trauma 2012
28 Civilian Tourniquet Consensus Data strongly suggests that tourniquet use saves lives. Adverse side effects associated with tourniquets appear to be manageable and do not appear to outweigh the benefits of tourniquet use.
29 American College of Surgeons All rights reserved Worldwide. Battlefield Lesson Resuscitation
30 Hemostatic Resuscitation
31 Civilian Trial Pragmatic Randomized Optimal Platelet and Plasma Ratio Trial (PROPPR) Holcomb et al JAMA 2015;313:
32 Whole Blood Resuscitation in Combat Fresh whole blood use by forward surgical teams in Afghanistan is associated with improved survival compared to component therapy without platelets Transfusion 2013 Shawn C. Nessen, Brian J. Eastridge, Daniel Cronk, Robert M. Craig, Olle Berséus, Richard Ellison, Kyle Remick, Jason Seery, Avani Shah, and Philip C. Spinella FWB in austere combat environments safe and independently associated with improved survival when compared with resuscitation with RBCs and FFP alone.
33 Whole Blood: Back to the Future Whole blood historically primary resuscitative solution for hemorrhagic shock. Transition to using component therapy occurred without evidence superior efficacy or safety. Misconceptions Whole blood must be ABO specific (O low titer 1:256) Whole blood cannot be leukoreduced Cold storage causes loss of platelet function Cold whole blood stored for up to 21 days has greater hemostatic capacity than blood components transfused in a 1 : 1 : 1 (in vitro) Spinella, Cap: Curr Opin Hematol 2016, 23
34 Battlefield Lesson Forward Transitioning Damage Control Philosophy American College of Surgeons All rights reserved Worldwide.
35 Pre-Hospital DCR Concepts Stop obvious hemorrhage Hemostatic adjuncts Correction of coagulopathy Judicious fluid management (permissive hypotension) Thermoregulation Minimize pre-hospital time ( Golden Hour is relative)
36 Golden Hour and the Gates Effect
37 Prehospital Time Noncompressible Torso Hemorrhage (GSW) Critical nature of prehospital time in patients with non-compressible torso hemorrhage. Evacuation times < 30 minutes not realistic, particularly in rural or austere environments. Emphasizes need to develop therapies to increase the window of survival in the prehospital environment. Alarhayem, Eastridge, et al: Mortality in Trauma Patients with Hemorrhage from Alarhayem, Torso Injury Eastridge: Occurs Time Long is Before the Enemy. the Am Golden J Surg 2016 Hour Presented at Southwestern Surgical Congress April 2016
38 Military Tactical DCR Forward FWB is the best prehospital resuscitation fluid 75 th Ranger Regiment program Type O Low Titer Anti-A, Anti-B abs Donors pre-screened for typing, titers, and infectious diseases Use donor pool to transfuse casualties in shock
39 Civilian DCR Forward
40 Prehospital Plasma PAMPer Trial
41 Prehospital Blood Outcomes
42 Prehospital Whole Blood Program development /proof of concept in process at several institutions Mayo Clinic University of Pittsburgh University of Texas Health San Antonio / San Antonio Military Medical Center
43 DCR Forward Versus Scoop and Run or Stay and Play? Advanced providers? Critical care capabilities Blood products Surgical capability enroute
44 UK MERT ISS 1-9 ISS ISS > 20 Observed Mortality Expected Mortality Apodaca et al: Performance improvement evaluation of forward aeromedical evacuation platforms in Operation Enduring Freedom.
45 Battlefield Continuum of Care Proof of Concept Forward Surgery Route from Injury to Definitive Care BAS Level 1 CASEVAC 1 Hour Forward Surgical teams Level 2 Surgical Capability TACTICAL EVAC 24 Hours Combat Support Hospital, EMEDS, Fleet Hospital Level 3 STRATEGIC EVAC Hours Definitive Care Level 4
46 Bidirectional
Trauma and Injury Subcommittee: Battlefield Research, Development, Test and Evaluation Priorities. Norman McSwain, MD Subcommittee Member
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