The NIHR Clinical Research Network

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1 The NIHR Clinical Research Network Andra Cosma Assistant Research Delivery Manager, South London Amal Qureshi Senior Portfolio Officer, North Thames

2 (CRN) The (CRN) is the research arm of the NHS. The is made up of 15 Local Clinical Research Networks that cover the length and breadth of England. These local networks coordinate and support the delivery of research across the NHS in England. We support research across 30 different health specialities.

3 15

4 Objectives Increase the number of participants recruited into NIHR CRN Portfolio studies. Increase the proportion of studies in the NIHR CRN Portfolio delivering to recruitment target and time. Increase the number of participants recruited into Dementias and Neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio

5 CRN Vision Clinical Research is an integral part of healthcare for all. The NIHR CRN supports clinical research infrastructure throughout England, which is working towards increased access for patients to new and better treatments in the NHS. The CRN currently recruits over 600K patients annually into clinical studies and supports a national portfolio of research from a wide variety of disciplines. Evidence clearly shows research active trusts have better patient outcomes

6 CRN Support We provide researchers with the practical support they need to make clinical studies happen in the NHS, so that more research takes place across England, and more patients can take part. This practical support includes: 1. Reducing the red-tape around setting up a study. 2. Enhancing NHS resources, by funding the people and facilities needed to carry out research on the ground. 3. Helping researchers to identify suitable NHS sites, and recruit patients to take part in research studies. 4. Advising researchers on how to make their study work in the NHS environment

7 How we support research- on the ground NHS Service Support Costs are the additional patient care costs associated with the research, which would end once the R&D activity in question had stopped, even if the patient care involved continued to be provided. Examples of NHS Service Support Costs: 1. The processing of the patient record to identify patients who may be suitable to approach to ask if they wish to participate in a research project. 2. Obtaining informed consent. 3. Additional investigations, assessments and tests where the results are required by the patient s care team to ensure patient safety and where arrangements are in place to feed the results back to the clinician.

8 How can the CRN help? Study Support Service- helps researchers and the life sciences industry plan, set up and deliver high quality research to time and target in the NHS in England. Delivery support: Trust Activity Based Funding & Negotiated funding, Flexible Delivery Staff, Contingency funding, Strategic funding. Training- Good Clinical Practice Performance management- Recruitment to Time & Target RAG reports.

9 Dementia and Neurodegeneration (DeNDRoN) The DeNDRoN specialty supports the set up and delivery of clinical research in the NHS in a range of dementia and neurodegenerative diseases Our job is to ensure that studies into DeNDRoN, that are included in our national portfolio of research receive the right support to make sure they are delivered successfully in the NHS

10 Dementia Research within CRNs The Government s Challenge on Dementia sets out the ambition for England to be the best place in the world to DeNDRoN diseases by UK Dementia research is fully embedded in NHS clinical practice Across the country, there are expertise in all stages and types of dementia, from pre-symptomatic through mild cognitive impairment to more advance stages, including: Alzheimer s disease Lewy body dementias vascular cognitive impairment mixed dementias frontotemporal dementia

11 DeNDRoN studies across all CRNs Number of studies There has been substantial increase in the number of studies across the country over the past decade. Financial Year

12 DeNDRoN recruitment across all CRNs Recruitment

13 Top recruiting Dementia studies within North Thames Study Study ID North Thames Recruitment MARQUE VALID WPs 3/ Total Study recruitment MRC National Survey of Health and Development Neuroimaging substudy A very CI-dense region Investigators interest in both interventional and observational studies Interest shown in Join Dementia Research to recruit patients and advertise studies. The number of patients registering on JD has increased significantly within North Thames.

14 Thank you Any questions?

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