NIHR Funding Opportunities

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1 NIHR Funding Opportunities David King Newcastle 12 th May, 2008

2 Consultation 2005 New Government Strategy 2006

3 Best for Best Health Vision To create a health research system in which the NHS: supports outstanding individuals working in world-class facilities conducting leading-edge research focused on the needs of patients and the public

4 Investigators & Senior Investigators Faculty Trainees Associates Infrastructure Clinical Networks Clinical Facilities & Centres Universities NHS Trusts Patients & Public Projects & Programmes Units & Schools Governance Systems Systems Information Systems

5 NIHR - May 2008 The following new research infrastructure is up and running: networks in diabetes, stroke, dementias and neurodegenerative disease, and medicines for children Primary care research network Technology platforms for diagnostic imaging Clinical Facilities Experimental Cancer Medicine Centres Biomedical Centres Centres for NHS Patient Safety & Service Quality Biomedical Units Flexibility and Sustainability Funding

6 NIHR - May 2008 Implementation is underway for the following research infrastructure: Comprehensive Network Collaborations for Leadership in Applied Health & Care

7 NIHR Clinical Network Infrastructure Clinical Networks Clinical Facilities & Centres UKCRN Co-ordinating Centre established Six topic-specific Networks established by 2006, each with co-ordinating centre and local networks (Cancer; Mental Health; Medicines for Children; Diabetes; Stroke; Dementias & Neuro-degenerative Diseases. One Primary Care Network with 8 local networks established October 2006; One Comprehensive Network with 25 local networks established April 2007, to be fully operational in 2008

8 TOPIC CLINICAL RESEARCH NETWORKS CANCER STROKE DIABETES Local Networks DEMENTIA + MEDICINES in CHILDREN MENTAL HEALTH UK Clinical Network (UKCRN)

9 NIHR Comprehensive Network

10 Clinical Facilities & Centres Infrastructure Clinical Networks Clinical Facilities & Centres Wellcome Trust Clinical Facilities Four CRFs in England NIHR Clinical Facilities Four CRFs Clinical Infrastructure Initiative Major UKCRC joint initiative led by Wellcome Trust funding 12 CRFs (9 in England) Experimental Cancer Medicine Centres Joint initiative between CRUK and UK Health Departments under umbrella of National Cancer Institute funding 17 centres (13 in England) plus 2 in development

11 Infrastructure Clinical Networks Clinical Facilities & Centres NIHR Centres for NHS Patient Safety & Service Quality Investigate ways to improve the safety, quality and effectiveness of the services the NHS provides to its patients and the public International Selection Panel chaired by Professor Peter Pronovost (Johns Hopkins) Two Centres selected and two Development Grants awarded Funding commenced April 2007 ( 10m over five years)

12 NIHR Biomedical Centres Infrastructure Clinical Networks Clinical Facilities & Centres Drive innovation in the prevention, diagnosis and treatment of ill-health and to translate advances in biomedical research into NHS practice International Selection Panel chaired by Professor John Savill (Edinburgh) Five Comprehensive and six Specialist Biomedical Centres selected Funding commenced April 2007 ( 450m over five years plus 45m capital) 7 th Specialist Biomedical Centre established April 2008

13 Infrastructure Clinical Networks Clinical Facilities & Centres NIHR Biomedical Units Support translational clinical research in priority areas of high disease burden and clinical need currently under-represented in the Biomedical Centres: - Cardiovascular Disease - Deafness and Hearing Problems - Gastrointestinal (including Liver) Disease - Musculoskeletal Disease - Nutrition, Diet and Lifestyle (including Obesity) - Respiratory Disease Units expected to develop capacity to submit credible bid for Biomedical Centre status in future competition 12 units established from 1 st April 2008 (each with funding of 3.75m over four years)

14 Infrastructure Clinical Networks Clinical Facilities & Centres Collaborations for Leadership in Applied Health & Care Will undertake high-quality applied health research focused on the needs of patients and support the translation of research evidence into practice in the NHS Will comprise a partnership between Academia and the NHS across the widest possible local geographic area. Address key recommendations of Sir David Cooksey's Review of UK Health and the CMO s High Level Review of Clinical Effectiveness Up to 50m available over five years from October 2008, with individual Centres receiving 5-10m

15 Investigators & Senior Investigators Faculty Trainees Associates Infrastructure Clinical Networks Clinical Facilities & Centres Universities NHS Trusts Patients & Public Projects & Programmes Units & Schools Governance Systems Systems Information Systems

16 NIHR - May 2008 The following new research funding streams are up and running: for Patient Benefit - responsive for Innovation, Speculation & Creativity - responsive HTA Pragmatic Clinical Trials - responsive SDO Limited Calls - responsive Programmes of Applied - responsive Healthcare Technology Co-operatives - responsive School for Primary Care - limited invitation

17 CREATE REFINE EVALUATE APPRAISE USE Basic - MRC and others National Institute for Health for Innovation, Speculation & Creativity Healthcare Technology Cooperatives NEAT HTD Biomedical Centres and Units Patient Safety and Quality Centres for Patient Benefit NHS Purchasing & Supplies Agency Programme Grants for Applied Health Technology Assessment Service Delivery & Organisation National Institute for Health & Clinical Excellence Challenge Fund for Innovation NHS CfH Capability Programme Collaborations for Leadership in Applied Health and Care Centre for Evidence-based Purchasing Appraisals & Guidance National Institute for Innovation & Improvement Clinical Guidelines National Innovation Centre Support for Commissioners and Providers World-class Commissioning Primary Care Trusts NHS Providers. This diagram illustrates how the NIHR s major research initiatives fit into the innovation pathway. The pathway starts with the creation of an innovation which would include basic research in a laboratory, through to its use to in a patient care setting. The diagram is not intended to show formal relationships between programmes and organisations. This pathway covers the full range of interventions - pharmaceuticals, biologicals, biotechnologies, procedures, therapies and practices - for the full range of health and health care delivery - prevention, detection, diagnosis, prognosis, treatment and care. Patient Care

18 Programme Grants for Applied Supports applied health research to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality) Maximum award 2m for up to five years Programme Director - Professor Adrian Grant Particular emphasis on conditions causing significant disease burden, where other research funders may not be focused, or there is insufficient funding available Two funding rounds per annum Builds to 75m per annum Projects & Programmes Units & Schools

19 for Patient Benefit (RfPB) Supports high quality Health Services and Public Health of relevance to the NHS Maximum award 250k for up to three years Programme Director - Professor Celia Davies 10 Regional Funding Committees, three funding rounds per year Up to 25m p.a. available for this programme by 2009/10 Projects & Programmes Units & Schools

20 Health Technology Assessment Supports research which provides information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS Programme Director - Professor Tom Walley Funding increasing from 11m to 40m per year New Pragmatic Clinical Trials Programme Additional research in Clinical Network areas; public health; needs of NICE Projects & Programmes Units & Schools

21 Service Delivery and Organisation Aims to improve health outcomes by: producing research evidence that improves practice in relation to the organisation and delivery of health care building capacity to carry out research amongst those who manage, organise and deliver services and improve their understanding of research literature and how to use research evidence Programme Director Stephen Davies Annual budget is planned to grow to 12.5 million by 2009/10 Projects & Programmes Units & Schools

22 for Innovation Speculation and Creativity (RISC) Supports new speculative and radical health research proposals that could lead to a step change in the care and management of patients Funding will build to 5m per year Up to 100,000 per project for Months 50 awards each year planned Programme Director - Malcolm Lowe-Lauri Scheme launched April awards in first round Second round launched in March 2008 Projects & Programmes Units & Schools

23 Invention for Innovation Programme will help accelerate the take-up and use of proven new treatments and devices by the NHS and will initially comprise: The New and Emerging Applications of Technology (NEAT) programme The Health Technology Devices programme (HTD) The Department of Health s R&D Directorate s contribution to the piloting of Healthcare Technology Co-operatives (HTCs) A Challenge Fund for Innovation Projects & Programmes Units & Schools

24 NIHR School for Primary Care Comprises the leading academic centres for primary care research in England Focus is on research to improve everyday practice in primary care Academic departments of primary care rated as 5 or 5* in the 2001 RAE became founding members of the School (Birmingham, Bristol, Cambridge, Manchester, Oxford) Professor Martin Roland (Manchester) appointed as Director of the School Funding commenced in March 2007 ( 1m in 2006/07, 3m pa thereafter) Projects & Programmes Units & Schools

25 Efficacy & Mechanism Evaluation Programme (EME) Funded by MRC and administered by NIHR Supports clinical trials and evaluative studies which: add significantly to understanding of biological or behavioural mechanisms and processes explore new scientific or clinical principles evaluate clinical efficacy of interventions where proof of concept in humans has already been achieved develop or test new methodologies Projects & Programmes Units & Schools

26 NIHR - May 2008 In some areas, particularly new research funding initiatives, numbers of projects funded and expenditure has been less than planned This is the direct result of two factors: a low applied research capacity due to historical underinvestment in this area the use by all NIHR peer review committees of the highest standards of research excellence

27 Specific Problems With Programme Grant Applications Failure to meet basic eligibility criteria Failure to demonstrate importance of topic Failure to demonstrate likelihood of patient benefit Failure to meet stated definition of applied health research Lack of appropriate multidisciplinary involvement Insufficient input into proposal by named applicants Insufficient depth of detail of research methods Unfocused proposals which do not represent a coherent programme of research. Over-ambitious proposals Projects & Programmes Units & Schools Read the guidance!

28 Characteristics of a Strong Programme Grant Application Excellent track record in applied health research Appropriate methodological expertise Addresses important research area with likelihood of patient/nhs benefit within 3-5 years Appropriate balance between breadth and depth ambitious (but not over-ambitious), broad and coherent programme of work realistic in scope and scale deliverable Well written and clearly presented proposal Appropriate arrangements for PPI Clear recognition of challenges Clear justification of resources Projects & Programmes Units & Schools

29 Design Service Aim is to increase the number and proportion of high quality applications for funding for applied people-focused health and social care research. RDS will help researchers to prepare research proposals for submission to national, peerreviewed funding competitions, eg RfPB National network of 10 RDS services one covering each of the 10 SHA geographical areas Funding up to 1m per annum for each RDS Projects & Programmes Units & Schools

30 Investigators & Senior Investigators Faculty Trainees Associates Infrastructure Clinical Networks Clinical Facilities & Centres Universities NHS Trusts Patients & Public Projects & Programmes Units & Schools Governance Systems Systems Information Systems

31 Investigators & Senior Investigators Faculty Trainees Associates NIHR Faculty Aims to: Attract, develop and retain the best research professionals to conduct and support people-based research Focus the talents of faculty members on health research meeting current and future needs of patients and the public Value both leaders and collaborators in health research. Provide ongoing support to academic training paths of all healthcare professionals and other key disciplines Support appointment and retention of key staff undertaking people-based research First NIHR Senior Investigators appointed from 1 st April 2008

32 Investigators & Senior Investigators Faculty Trainees Associates Infrastructure Clinical Networks Clinical Facilities & Centres Universities NHS Trusts Patients & Public Projects & Programmes Units & Schools Governance Systems Systems Information Systems

33 NIHR - May 2008 The following new research systems are up and running: Regulatory and Governance Advice Service Passport National Ethics Service Implementation is underway for the following research systems: IRAS Governance as part of the Comprehensive Network Central Sign-off for research in the NHS Integrated information system for researchers and R&D management

34 NIHR website has all the latest information:

35 OSCHR Cooksey Review recommended creation of an Office for Strategic Coordination of Health - OSCHR Mission: to facilitate more effective translation of health research into health and economic benefits in the UK Role: to ensure a more strategically-coherent approach across publicly-funded health research in England and the UK Approach: new, light-touch organisation Structure: jointly-funded and jointly-staffed office of DH and DIUS

36 HM Treasury DH OSCHR DIUS NIHR DAs Coordinated Health Strategies MRC

37 HM Treasury SofS DH DG R&D NIHR OSCHR DAs Translational Medicine Board Public Health E-Health SofS DIUS DG S&I MRC

38 HM Treasury SofS DH DG R&D NIHR OSCHR DAs Translational Medicine Board Public Health Board E-Health Methodology Human Capital SofS DIUS DG S&I MRC

39 OSCHR has: Forged agreement on principles of working on blocks of work Now working jointly NIHR-MRC working groups - fast & focused lead organisation model detailed operational plans Is engaging stakeholders membership of Boards formal and informal consultation

40 Coordinated Health Strategy Will: sustain the UK s excellent basic research increase the funding for translational research further increase the funding for applied research particularly evaluation and trials gives lead responsibility for key elements to NIHR or MRC

41 NIHR Funding Opportunities David King Newcastle 12 th May, 2008

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