Anna Hegerius, MSc Pharm Team Leader, Education & Training
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1 Anna Hegerius, MSc Pharm Team Leader, Education & Training
2 UMC/WHO guidelines (2000) Available in: English Spanish French Russian Italian Korean Portuguese 2 Anna Hegerius, Uppsala Monitoring Centre
3 3 Anna Hegerius, Uppsala Monitoring Centre
4 Success factors Mandate Funding Organization Scope Resources Routine operations Data collection Data analysis Communication Actions/Results Partnerships 4 Anna Hegerius, Uppsala Monitoring Centre
5 Mandate A political mandate with a legal framework National pharmacovigilance policy Voluntary or mandatory reporting? 5 Anna Hegerius, Uppsala Monitoring Centre
6 Mandatory Reporting for HPs Austria Bulgaria Croatia Czech Republic France Greece Hungary Italy Lithuania Mongolia Morocco Norway Oman Russia Slovak Republic Spain Sweden Switzerland 6 Anna Hegerius, Uppsala Monitoring Centre
7 7 Anna Hegerius, Uppsala Monitoring Centre
8 Mandatory Reporting for MAHs ICH-countries and many others: Expedited reporting Serious, unexpected reactions within 15 days Non-serious in Periodic Safety Update Reports New EU legislation in July Anna Hegerius, Uppsala Monitoring Centre
9 Funding A designated budget for routine operations 9 Anna Hegerius, Uppsala Monitoring Centre
10 Affiliation Where to establish the National Centre? Drug regulatory authority Poison information or drug information centre University institution Hospital department Independent foundation/organization Where do you find competent and dedicated people? 10 Anna Hegerius, Uppsala Monitoring Centre
11 Organization How to organize the PV system? Centralized Network of regional centres Sentinel sites 11 Anna Hegerius, Uppsala Monitoring Centre
12 Countries with regional network Argentina Brazil Canada China Cuba France Ghana Italy India the Netherlands Nigeria Norway Poland Portugal Russia Spain Sweden Switzerland Thailand Uganda United Kingdom 12 Anna Hegerius, Uppsala Monitoring Centre
13 Patient Health professional Hospital DTC Regional Centre Manufacturer Drug Authority 13 Anna Hegerius, Uppsala Monitoring Centre
14 Scope of pharmacovigilance Adverse reactions Inadequate/incorrect use Medication errors Dependence, abuse and poisoning Antibiotic resistance Other safety challenges Immunization programmes Other public health programmes Product quality problems Failing GMP Lack of efficacy Counterfeiting 14 Anna Hegerius, Uppsala Monitoring Centre
15 Scope of pharmaceuticals Include or exclude? Traditional medicines Biologicals incl. vaccines Blood products Medical devices Cosmetic/hygiene products Functional food Veterinary medicines 15 Anna Hegerius, Uppsala Monitoring Centre
16 Resources (human) Pharmaceutical competence Medical competence Administrative assistance Dedication Education Formal training Visit established centre 16 Anna Hegerius, Uppsala Monitoring Centre
17 Resources (technical) Computer with printer and scanner Standard office software ICSR management system» VigiFlow Literature sources Internet access, Telephone, fax Photocopier 17 Anna Hegerius, Uppsala Monitoring Centre
18 Routine operations (data collection) How to aquire data - reporting form? Main vehicle for information Spend time and resources on it! Ask for the important items Attractive and simple design Be inspired by what others have done Make a pilot form and test it Design of form depending on scope 18 Anna Hegerius, Uppsala Monitoring Centre
19 Routine operations (data collection) Who should be requested to report? Physicians Traditional therapists Pharmacists Nurses Dentists Manufacturers Public health managers NGOs Patients/care takers General public Consider amount of info versus quality of data and work required 19 Anna Hegerius, Uppsala Monitoring Centre
20 Routine operations (data analysis) Coding system? WHO-ART or MedDRA Method of causality assessment? WHO/UMC or Naranjo (most commonly used) Root-cause analysis for medication errors Method of signal detection 20 Anna Hegerius, Uppsala Monitoring Centre
21 Advisory Committee National Centre Preliminary case assessment Case follow-up Case recording Carry out actions Advisory Committee Final case assessment Promote reporting Analyze problems Provide recommendations Propose actions 21 Anna Hegerius, Uppsala Monitoring Centre
22 Routine operations (communication) Feed-back routines Individual response Adverse reactions newsletter Website Social media Promotional/educational activities 22 Anna Hegerius, Uppsala Monitoring Centre
23 Actions/results (use of PV data) Drug information Individual Formulary/SPC Drug Regulation Essential Drugs List Therapeutic guidelines Teaching Research 23 Anna Hegerius, Uppsala Monitoring Centre
24 Partnerships Drug regulatory authority Public health/immunization programmes Pharmaceutical companies Academic institutions Professional associations Consumer and patient organizations Media Pharmacovigilance centres in other countries WHO-UMC 24 Anna Hegerius, Uppsala Monitoring Centre
25 International PV network Share your ICSRs Experience Knowledge Enthusiasm Challenges Receive VigiBase access Medicine safety information Terminologies and software Support and guidelines Publications Join the WHO Programme for International Drug Monitoring! 25 Anna Hegerius, Uppsala Monitoring Centre
26 Summary Functions of PV system Data collection Data management Signal detection Safety issue assessment Decision-making Action and Communication 26 Anna Hegerius, Uppsala Monitoring Centre
27 Thank you for your attention! 27 Anna Hegerius, Uppsala Monitoring Centre
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