Technion Technology Transfer Connecting Partners to Find Solutions

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1 Technion Technology Transfer Connecting Partners to Find Solutions 2016

2 The Global Startup Ecosystem Ranking 2015

3 Israeli Venture Capital Ecosystem : VC Investments - Global Comparison When it comes to innovation and creativity, Israel is second only to the Silicon Valley Steve Ballmer, ex CEO, Microsoft Tel Aviv, $b % change 2015 Vs US 57 Europe 48 China 100 Israel US Europe & UK Israel China E Note: 2015E is based on first half of 2015 actual Sources: Israel - IVC Research Center, US KPMG/CB Insights, NVCA - PWC/Thomson Reuters Europe, China KPMG/CB Insights, Dow Jones Venture Source

4 Israeli High-Tech Capital Raising ($M) Source:

5 Number of Israeli High-Tech Companies by Deal Size (%) Source:

6 The Technion Leading Position Leading in Excellence Home to three Nobel Prize Laureates since 2004 Ranked among the Top 25 engineering schools in the world, Business Insider report Number 18 in the field of Computer Sciences, recent Shanghai Ranking Ranked 31 st in approved number of U.S. patents, 2014 U.S Academy of Investors Index Leading in Innovation Ranked 6th worldwide in entrepreneurship and innovation, according to recent MIT survey A leading source for Israeli innovation in science and technology Leading in Entrepreneurship 7th in the Bloomberg ranking: "Top 10 Colleges for Tech CEOs" of companies worth $1 billion or more.

7 Companies & Management Positions by Technion Alumni 1,602 companies were founded and/or managed by Technion alumni Source: Samuel Neaman Institute, 2015 establishment year GGA Galileo

8 Companies & Management Positions by Technion Alumni 1,602 companies were founded and/or managed by Technion alumni (establishment year ). 59% are at revenue stage (active companies): Initial Revenues (40%); Revenue Growth (19%) 53% - ICT; 24% Life sciences 79% of the companies employ less than 50 employees Companies established /managed by Technion alumni have directly employed about 95,500 jobs 34 foreign R&D centers in Israel were established or managed by Technion alumni 1,319 companies (in Israel) established/managed by Technion alumni Total capital raised by Technion related companies : Over $ 6,406M Volume of Technion related companies (merged /acquired): Over $ 28,063M Source: Samuel Neaman Institute, 2015

9 Companies on NASDAQ Established /Managed by Technion Alumni 72 Israeli companies on NASDAQ. 42 of them (58%) founded or managed by Technion alumni 64 Technion alumni established /managed 42 companies that are currently traded on NASDAQ (29 are founders of companies and 35 serve in senior positions). NASDAQ Market Cap of companies established or manages by Technion alumni is ~ 22 Billion$ (Total Market cap of the Israeli companies on NASDAQ is ~ 98 Billion $). Source: Samuel Neaman Institute, 2015

10 Business Challenges in Technology Transfer Difficulties in assessing cost or what market might bear. Buyers don't know what they are willing to pay. Dynamics of the market place is unknown. Difficulty assessing cost of goods. Difficulty assessing margins, or savings. competitive landscape mostly unknown. Financial forecast mostly unknown. Impact in the market place mostly unknown Capital investment required to bring product to the market unclear. Many technologies are manufacturing process related, and it is challenging to estimate the savings involved. Cost of human resources required is often unknown, so is their availability. Difficulty in assessing the regulatory pathway of the product to the marketplace.

11 Business (cont.) Challenges in Technology Transfer Number of potential applications mostly unknown. Barriers to market entry mostly unknown. Difficulty in making assumptions regarding external factor affecting commercialization. Technology Most innovations are at a concept level of development. Nature and extent of problems remaining to be solved mostly unknown. IP Period required to develop the IP and hence the remaining life of the patents to be developed unclear. Number of potential applications mostly unknown. IP environment is unclear. Unclear whether it will be possible to obtain adequate IP protection.

12 Technology Readiness Levels Level 1 Level 2 Basic Principals observed and reported Technology concept and / or application formulated Level 3 Level 4 Analytical and experimental critical function and / or characteristic proof of concept Component validation in laboratory environment Level 5 Level 6 Component validation in relevant environment System / Subsystem model or prototype demonstration in a relevant environment Level 7 System prototype demonstration in an operational environment

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15 Principal University and Pharmaceutical Company Partners Associated with the Top Ten Biotechnology Products in 2002 Source: Nature Biotechnology ( 2003) ,21

16 Development Graph Levels Potential Investors Government Incubators Venture Capital Pharma Pharma 15% 16% 14% Investment (Millions $) % 8% 12% 12% 10% 8% 6% Average Royalties % Feasibility Preclinical Phase I Phase II Phase III 4% 2% 0% Chances of Commercialization Required Investment Average Royalties

17 The Life Science Investor Landscape Source: Nature Biotechnology, JANUARY

18 T³ - Technion Technology Transfer on a Tug-Boat Mission

19 Technion Ecosystem Success Stories

20 T 3 STATS (10/ /2015) Over $ 33M in revenue Over 40 commercialization agreement Over 70 affiliated companies Patents Over 640 active patent families ~ 100 new invention disclosures Over 460 patent families available for commercialization Over 780 patents granted Investments Investments in TRDF affiliated companies: over $200M TIOF investments: over $1.8M

21 Sagi Ben-Moshe

22 IVCAM History Technology started as a project at the Technion GIP Lab Invision Biometrics startup formed, in Yokneam Technion patents acquired and main team established Prof. Alex Bronstein, Prof. Kimmel, and Prof. Michael Bronstein Israel Prize winner Prof. Motti Segev Intel acquired Invision Biometrics From POC to Real Product Technion, 2001

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24 Peter Van Vlasselaer

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28 NanoVation GS

29 TVF The Investment Opportunity Deal Flow Sourcing Channels The Technion ecosystem generates quality technology investable opportunities every year TVF will work across main sourcing channels to identify the most attractive investment opportunities Technion Faculty, Alumni, Research Associates, Students T3 Technology commercialization & Transfer activities, IP portfolio TRDF Accelerators, Incubators, special Entrepreneurship, Post Doctorates and other special Programs TVF Haifa, NYC, China Team Personal Network, Angels & VC Community Israel & Haifa High Tech Ecosystem, Industrial parks, Industry Other Domestic & Global VC Funds, Strategic Investors - Targeting Technion Innovation

30 TVF The Investment Opportunity Focus, Criteria, Process Sector Stage $20m Innovative early stage developed technologies Contrarian approach Focus Information Technology Internet / Mobile, Iota Cyber Sustainable Technology Life Science Medical Devices Digital Health Pre Seed $50-150k Seed $ k A $2-4m B C D $5-8m Criteria Process Focus, Criteria, Process Capital Efficiency Innovative Technology, Product Market: Size, Growth Management: Experience, Structure Sustainable Business Model Strategic Co-investors, Syndication Winners - full cycle support, maintain 20-25% equity until exit Lead investor : DD, TS, Agreement, Syndication Support :Strategy, Recruitment, Introductions, Capital Raising, Exit Initial Follow-on Exit A B C D +10X Category Leaders Investment Period 5 years Disciplined pace : deploy $20-30m annually Portfolio Companies

31 Benny Soffer T 3 - Technion Technology Transfer sofferb@trdf.technion.ac.il