Research, Funding and Grantsmanship: Fellowship to Assistant Professor - Postdoctoral Training Program in Cardiovascular Disease -
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1 Research, Funding and Grantsmanship: Fellowship to Assistant Professor - Postdoctoral Training Program in Cardiovascular Disease - November 25, 2013 Jaime S. Rubin, Ph.D. jsr9@columbia.edu, Dept. of Medicine College of Physicians and Surgeons Columbia University
2 Topics to be Discussed Types of Awards Fellowships (F s), Training grants (T s), Career Development awards (K s),( Research grants (R s), Loan Repayment Program Funding Agencies Federal National Institutes of Health, AHRQ,, HRSA Voluntary Health Organizations, Professional Societies, Foundations, Industry, Other Planning & Organizing a Research Proposal
3 Topics to be Discussed Types of Awards Fellowships (F s), Training grants (T s), Career Development awards (K s),( Research grants (R s), Loan Repayment Program Funding Agencies Federal National Institutes of Health, AHRQ,, HRSA Voluntary Health Organizations, Professional Societies, Foundations, Industry, Other Planning & Organizing a Research Proposal
4 National Institutes of Health National Cancer Institute National Eye Institute National Heart, Lung, & Blood Institute National Human Genome Research Inst National Institute on Aging National Inst of Alcohol Abuse & Alcoholism National Inst of Allergy & Infectious Diseases National Inst of Arthritis & Musculoskeletal & Skin Diseases National Institute of Child Health & Human Development National Inst on Deafness & other Communication Disorders National Inst of Dental & Craniofacial Research National Institute of Diabetes & Digestive & Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Institute of General Medical Sciences National Inst of Biomedical Imaging and Bioengineering National Institute of Mental Health National Inst of Neurological Dis and Stroke National Institute of Nursing Research National Library of Medicine National Ctr for Complementary & Alt Medicine National Inst on Minority Health & Health Disparities National Ctr Adv Translational Sciences John E. Fogarty International Center Office of the Director Center for Scientific Review Center for Information Technology NIH Clinical Center Adapted from: NIH (DRG) - Peer Review of NIH Research Grants Applications
5 Topics to be Discussed Types of Awards Fellowships (F s), Training grants (T s), Career Development awards (K s),( Research grants (R s), Loan Repayment Program Funding Agencies Federal National Institutes of Health, AHRQ,, HRSA Voluntary Health Organizations, Professional Societies, Foundations, Industry, Other Planning & Organizing a Research Proposal
6 Not All Funding Opportunities Are the Same Different mission statements Career development (K s)( Research project (R s) Different funding Stipend/Salary Comprehensive research costs Different time frames Not renewable: 5 years (K s),( 3 years (F s), 2 years (T s) Renewable: 4years-5years (R01) each competitive period
7 Types of Awards Individual fellowships Training grants Career transition awards Career development awards Research grants Institutional Clinical & Translational Science Award (CTSA) Loan Repayment Program Administrative supplements Program Projects Cooperative agreements Subcontracts Contracts
8 Timeline of Funding for Junior Investigators T35 Training Grant Summer Research between 1 st and 2 nd Years Individual Post-doc Fellowship or Institutional Post-doc Training Grant slot Institutional K12 Career Development Slot Medical School Internship/ Residency Fellowship Research Years Instructor/ Assistant Professor Year-long Enhancement Research Program Career Transition Award Individual Mentored K Career Development Award
9 NIH Career Development Support to Independent Research Funding K12 K12 K08/K23 K23 K23 K08/K23 K12 Independent Grant Independent Grant Independent Grant Independent Grant Independent Grant
10 R01 Research Award Independent Investigator Funds research project Salaries of PI and other research personnel Supplies, reagents, etc Animal costs Patient care costs Core facilities Page charges for publications Multi-Year (4yrs 5yrs) Renewable (e.g. original grant + 2 renewals = 15yrs)
11 Timeline of NIH Funding for Junior Investigators T35 Training Grant Summer Research between 1 st and 2 nd Years Individual Post-doc Fellowship or Institutional Post-doc Training Grant slot Medical School Internship/ Residency Fellowship Research Years Instructor/ Assistant Professor Year-long Enhancement Research Program Career Transition Award
12 Career Transition Awards BWF: Career Awards for Medical Scientists To support physician-scientists scientists during the last years of a mentored postdoctoral/fellowship position and the beginning years of an independent faculty position. Must hold an M.D., D.D.S., D.V.M., Pharm.D.,., or equivalent clinical degree 75% effort to research-related related activities Funding: $700,000 over five years Postdoctoral/Fellowship Portion: Years 1 and 2 Annual Total: $95,000 Faculty Portion of the Award: Years 3-53 Annual Total: $170,000
13 Career Transition Awards NIH Pathway to Independence Award (K99/R00) 1-22 years as a mentored K award for post-docs Total/year: =$90,000 (salary and research expenses) 75% effort 3 years as an research support award for independent investigators Total/year:=$249,000 (salary and research expenses) Must have an independent research position Fund awards per year
14 Career Transition Awards American Heart Association (National) Fellow-to to-faculty Transition Award Provides funding for the crucial period of a physician- scientist s s career development which spans the completion of research training through the early years of the first faculty/staff position Training stage (1-3 3 yrs, $65,000 per year) and the first years of the first faculty/staff appointment ($132,000 per year), for a maximum of five years of support Citizenship: U.S. citizen/ Permanent resident/ Pending permanent resident, Visas (e.g. H1-B, O-1) O
15 Timeline of NIH Funding for Junior Investigators T35 Training Grant Summer Research between 1 st and 2 nd Years Individual Post-doc Fellowship or Institutional Post-doc Training Grant slot Medical School Internship/ Residency Fellowship Research Years Instructor/ Assistant Professor Year-long Enhancement Research Program Career Transition Award Individual Mentored K Career Development Award
16 Research Career Programs (K) Minimum Effort: e.g. 75% (sometimes 50%) Research & Career development activities Predominantly salary support Up to 5 years US citizen/permanent resident Reduce effort to 50% in last 2 years if PI of NIH research grant
17 Mentored Clinical Scientist Development Award (K08) Support to develop outstanding independent clinician research scientists Basic and translational science
18 Mentored Patient-Oriented Research Career Development Award (K23) Patient-oriented research: Research conducted with human subjects (or on material of human origin) for which an investigator directly interacts with human subjects Research areas: (1) Mechanisms of human disease, (2) Therapeutic interventions, (3) Clinical trials, and (4) Development of new technologies
19 Mentored Research Scientist Development Awards (K01) NHLBI: Diversity NHLBI: (a) Epidemiological Research (b) Biostatistics Research (c) Comparative Effectiveness Research
20 Research Career Development Awards
21 Research Career Development Awards awards 32.jpg
22 NHLBI: K23 awards - Success Rates
23 Agency for Healthcare Research and Quality (AHRQ) Mentored Clinical Scientist Development Awards (K08) Patient-Centered Outcomes Research (PCOR) Mentored Clinical Investigator Award (K08) Patient-Centered Outcomes Research (PCOR) Mentored Research Scientist Development Award (K01)
24 Timeline of NIH Funding for Junior Investigators T35 Training Grant Summer Research between 1 st and 2 nd Years Individual Post-doc Fellowship or Institutional Post-doc Training Grant slot Institutional K12 Career Development Slot Medical School Internship/ Residency Fellowship Research Years Instructor/ Assistant Professor Year-long Enhancement Research Program Career Transition Award Individual Mentored K Career Development Award
25 Mentored Clinical Scientist Development Program Award (K12) Support to an institution for career development experiences for clinicians leading to research independence Institutions recruit and select candidates into their programs Candidates must meet the same criteria as for the individual mentored clinical scientist development award
26 CTSA Awards: A Home for Clinical and Translational Science Clinical Research Ethics Trial Design NIH Biomedical Informatics Clinical Resources CTSA HOME Advanced Degree-Granting Programs Participant & Community Involvement Industry Biostatistics Regulatory Support Other Institutions Source: Zerhouni (NIH) [9/06]
27 Mentored Clinical Scientist Development Program Award (K12) CTSA - Clinical and Translational Scientist Award TRANSFORM Scholars Mentored Career Development program [Training and Nurturing Scientists for Research that is Multidisciplinary]
28 Degree Program in Patient-Oriented Research [POR] Comprehensive courses in clinical research Biostatistics, epidemiology, study designs, bioethics, legal and regulatory issues For the career development of clinical investigators
29 Research Career Development/ Scholar Programs American Heart Association Scientist Development Grant Doris Duke Charitable Foundation Clinical Scientist Development Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program
30 NIH Career Development (K ) Application Model for other career development/ scholar grant programs supported by voluntary health organizations, private foundations, and professional societies
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34 The Candidate Candidate s s Background Career Goals and Objectives: Scientific Biography
35 Candidate s s Background Personal background for this career path Other relevant training experiences Other research experiences Reasons for basic, clinical, translational, behavioral, multidisciplinary research, relevant publications
36 Career Goals and Objectives Unique expertise/scientific history Skills that are lacking Short-term term Career Goals Timeline for funded period Long-term Career Goals Scientific goals Mentoring goals Networking goals
37 Career Development/Training Activities During Award Period Review of didactic courses, clinical training, and research experiences to date New research skills/ knowledge required Identification of training modules required to fill gaps in knowledge in order to reach long term goals Mentors, Courses, Workshops and additional training, Conferences, Communication skills, Grant writing
38 Mentors/Advisory Committee Collaborators and Consultants Scientific area per mentor/committee member Schedule of meetings Faculty Member Name (Title) Name (Title) Name (Title) Name (Title) Name (Title) Name (Title) Name (Title) Career Development and Research Training Mentors and Advisors Role Mentor Co-Mentor Advisory Board Member Advisory Board Member Advisory Board Member Collaborator Consultant Area of Expertise
39 Environment and Institutional Commitment to the Candidate Description of Institutional Environment Institutional Commitment to the Candidate s Research Career Development
40 Timeline of NIH Funding for Junior Investigators T35 Training Grant Summer Research between 1 st and 2 nd Years Individual Post-doc Fellowship or Institutional Post-doc Training Grant slot Institutional K12 Career Development Slot Medical School Internship/ Residency Fellowship Research Years Instructor/ Assistant Professor Year-long Enhancement Research Program Career Transition Award Individual Mentored K Career Development Award NIH Loan Repayment Program
41 NIH s Extramural Loan Repayment Program Up to $35,000 a year towards educational loan debt Conduct qualified research activities for at least 50% of their effort (or less than 20 hours per week) for a minimum of 2 years Qualifying educational loan debt equals or exceeds 20% of the applicant's institutional base salary
42 NIH s Extramural Loan Repayment Program Extramural Programs Clinical Research Health Disparities Research Clinical Researchers from Disadvantaged Backgrounds Pediatric Research Contraception and Infertility Research
43 LRP: Clinical Research New Applications -
44 LRP: Clinical Research Renewal Applications -
45 HRSA Loan Repayment Programs Health Resources and Services Administration/ Faculty Loan Repayment Program Health professions faculty from disadvantaged backgrounds agree to serve at a health professions college/university for 2 years. Federal government will pay up to $40,000 of the participant's student loans and provides funds to offset the tax burden.
46 NIH Career Development Support to Independent Research Funding K12 K12 K08/K23 K23 K23 K08/K23 K12 Independent Grant Independent Grant Independent Grant Independent Grant Independent Grant
47 R01 Research Award Independent Investigator Funds research project Salaries of PI and other research personnel Supplies, reagents, etc Animal costs Patient care costs Core facilities Page charges for publications Multi-Year (4yrs 5yrs) Renewable (e.g. original grant + 2 renewals = 15yrs)
48 R01 Research Grant Supports a discrete, specified project Comprehensive funding Modular budgets up to $250,000/year Multi-year Flexibility Most of the research that NIH supports is through this funding mechanism
49 R01-Equivalent grants: Applications, Awards, and Success Rates
50 Exploratory/Developmental Grants (R21) Encourages new, exploratory, and developmental research Pilot and feasibility studies 2 years of funding Budget: $275,000 over two years Not renewable
51 Small Research Grants (R03) Supports: Pilot or feasibility studies Collection of preliminary data Secondary analysis of existing data Small, self-contained research projects Development of new research technology 2 years of funding Budget: $50,000/year Not renewable
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56 NIH R01 Principal Investigators: Age 36 and Younger / Age 66 and Older
57 Early Stage Investigators No previous significant NIH independent research award e.g. R01 s Does not include: F s, F K s,, loan repayment program Within 10 years of terminal research degree/ completion of medical residency Extensions permitted Additional clinical training Family responsibilities
58 Early Stage Investigators: NHLBI FY13
59 R01- Equivalent grants, New (Type 1) Success rates, by career stage of investigator
60 Topics to be Discussed Types of Awards Fellowships (F s), Training grants (T s), Career Development awards (K s),( Research grants (R s), Loan Repayment Program Funding Agencies Federal National Institutes of Health, AHRQ, HRSA Voluntary Health Organizations, Professional Societies, Foundations, Industry, Other Planning & Organizing a Research Proposal
61 Voluntary Health Organizations American Heart Association National Collaborative Science Award Mentored & Clinical Population Research Award Fellow-to to-faculty Transition Award Scientist Development Grant Founders Affiliate Grant-in in-aid Mentored & Clinical Population Research Award Scientist Development Grant Postdoctoral Fellowship Predoctoral Fellowship Undergraduate Student Summer Fellowship Program Medical Student Research Program
62 Professional Societies American College of Cardiology (ACC)/ACCF Merck Research Fellowships in Cardiovascular Disease and Cardiometabolic Disorders $70,000 salary support for one year of research William F. Keating, Esq. Endowment Award $70,000 salary support for one year of research International Society for Cardiovascular Translational Research (ISCTR) Cardiovascular Translational Research Scholarship $60,000 salary support for one year of research Young Investigator Awards Competition
63 Private Foundations Doris Duke Charitable Foundation Clinical Scientist Development Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program
64 Topics to be Discussed Types of Awards Fellowships (F s), Training grants (T s), Career Development awards (K s),( Research grants (R s), Loan Repayment Program Funding Agencies Federal National Institutes of Health, AHRQ, HRSA Voluntary Health Organizations, Professional Societies, Foundations, Industry, Other Planning & Organizing a Research Proposal
65 When Preparing an Application: Read instructions Never assume that reviewers will know what you mean Refer to literature thoroughly and thoughtfully Explicitly state the rationale of the proposed investigation Include well-designed tables and figures Present an organized, lucid write-up
66 Elements of a Good Proposal Feasible Relevant Unique Innovative Clear Brief Consistent
67 Anticipate Questions and Answer them before they are asked
68 Investigator Competent Enthusiastic Thorough Professional
69 NIH: one round of applications
70 Pink Sheet: Reviewers Comments
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72 Bell Curve of Reviewer s Grant Applications Fine Definitely do not fund Definitely fund Great
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74 Poor Statistics
75 Research Resources not Adequately Described
76 Career Development Plan not Comprehensive
77 Figure Caption Font too Small
78 All Components of the Application are as Strong as Possible
79 Common Problems with Grant Applications from New Investigators Overly ambitious Not independent of previous mentor s s research Fishing expedition Not hypothesis driven Descriptive, not mechanistic project Unfocussed No or insufficient preliminary data Unrealistic budget Methodologies beyond the expertise of investigator or research team
80 Good Luck!
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