Partnership Opportunities with CSU C. Rick Lyons,M.D.,Ph.D

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1 Partnership Opportunities with CSU C. Rick Lyons,M.D.,Ph.D Director, Infectious Disease Research Center

2 Infectious Disease Research Center

3 Bricks and Mortar Regional Biocontainment Lab and BRB contain both low and high level biocontainment research laboratories ; BSL 3 leasing available Research Innovation Center ( RIC) First floor houses academicians from CSU. Second floor is made up of incubator BSL 2 labs leased to business and research partners and startups to enhance interactions with researchers and develop local entrepreneurial activity

4 Brick and Mortar: GMP manufacturing CSU faculty run Biomark operating GMP manufacturing within the RBL and has BSL 3 capability GMP manufacturing building is CSU owned and will be capable of producing pharmaceutical products and foster business interactions with CSU and its affiliates for their manufacturing needs

5 IDRC Core Technologies Low to High Biocontainment rooms Pre clinical animal models Immunology and diagnostic Affymetrix Proteomic and Metabolomic analysis NextGen Sequencing Small scale GMP production

6 Multidisciplinary exposure Investigators from multiple disciplines increase collaborative activity, scientific expertise and enhance application of platform discoveries across several disciplines IDRC contains investigators from: College of Agriculture College of Engineering College of Veterinary Medicine and Biological Sciences

7 Business Incubator

8

9 BUSINESS INCUBATOR RIC SECOND FLOOR

10 Incubator Acceptance Criteria Our revised acceptance criteria are listed in priority: Any CSU- generated start-up company whose needs are consistent with the space within the RIC incubator and they meet due diligence regarding their basic business model. Non- CSU start-up companies who are good partners based on their desire and need to interact with researchers and utilize capabilities within the CSU domain. As expected, companies involved in infectious diseases will have the highest priority in this category although this is not required. Non- CSU companies who do not have any interactions with CSU but whose presence are a strategic fit for the IDRC mission. To a large degree we have tested this criteria over the last 18 months and this has resulted in 90-95% occupancy rate for that time. Therefore we feel that strategy is likely to lead to a sustainable occupancy model.

11 IDRC Impact Factor RIC Partner Selection Matrix High KromaTiD Metabologics Eflux Low Low CSU Connection High

12 Annual Square Footage Utilization by Category Public/Private Entity 21% Under Collaborative Agreement w/ CSU 79% CSU Startup 46% Non-CSU Start-up 54%

13 Client/Partner Selection 2013/2014 Lease Rates (prepared by CSU/CSURF REO) The Incubator rate structure has been established in a tiered fashion to encourage the leasing of space to start-up companies with a strong connection to both the IDRC and CSU. Full Service Gross Lease Rates (all operation, maintenance, utilities included) Type of Entity Class A Office $/sf/yr Class B Office $/sf/yr Basic Lab $/sf/yr BSL-2 $/sf/yr Specialty Spaces $/sf/yr Lease Rate Categories: CSU Program CSU Start-up Non-CSU Start-up Public/Private Entity Client Selection Criteria: 1.IDRC Impact Factor 2.CSU Connection CSU Programs (auxiliary, contract & grants as allowable) CSU Start-up * Non-CSU Start-up * Public/Private Entity - No Sponsored Research Agreement (Full Market Rate) * under collaborative agreement with CSU

14 IDRC Business Partner Start Up Investors Business management Technology Capabilities Competitive Funding CSURF Innosphere IDRC Faculty Cores Facilities

15 Metrics for success 1) Graduated Startups a) CSU Born b) External- Northern Colorado economy 2) Funded collaborative research with CSU faculty a) SBIRs/STTRS; 3) Interactions with IDRC 4) Patents/disclosures 5) Jobs created

16 GMP Mission Fill the gap for early phase product development and manufacturing capability between academic, translational research and start up firms

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