EUROTHROMBOSIS SCIENCE 2008: FOCUS ATHEROTHROMBOSIS December 11, 12, 13 Barcelona (Spain)

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1 Dear Participant, It is a pleasure to welcome you to the EUROTHROMBOSIS SCIENCE 2008: we are organizing in Barcelona. This meeting is an activity of the Working Group on Thrombosis of the European Society of Cardiology and this time it is sponsored by the Spanish Society of Cardiology Section of Coronary Heart Disease and its Working Group on Cardiovascular Thrombosis. I am pleased to announce this meeting that will help to develop intense scientific relations among groups interested in unveiling the causes, mechanisms, clinical implications, and therapeutical options in atherothrombosis. I wish you have an excellent stay in Barcelona and a very profitable congress. Lina Badimon

2 General Information VENUE OF THE CONGRESS Congress will be held at the Cardiovascular Research Centre c/. Sant Antonio Mª Claret, 167 Hospital de la Santa Creu i Sant Pau- Pavelló del Convent Barcelona, Spain 11th 13th December 2008 SCIENTIFIC, LOGISTIC & TECHNICAL ORGANIZATION SECRETARY Prof. Lina Badimon Secretary: MªJosé Bartolomé Address: Cardiovascular Research Foundation C/ Sant Antonio Mª Claret, 167 Hospital de la Santa Creu i Sant Pau - Pabellón del Convento Barcelona, Spain Tel: Fax: mbartolome@csic-iccc.org

3 Standard Registration REGISTRATION Early registration fee (before September 15): 200,- Late registration fee (between September 15 and November 14): 250,- This includes participation in the scientific program, refreshments and lunches during the congress, participation in the dinner party on December 12. One day ticket registration Registration for a one day ticket is possible until November 14. Costs per day: 50,- This includes participation in the scientific program, refreshments and lunches during the congress. Students / cardiologists in training Registration for students or cardiologists in training is free of charge. This includes participation in the scientific program, refreshments and lunches during the congress and participation in the dinner party on December 12. How to register A registration form can be downloaded here. Registrations can be made by faxing the registration form (before November 14) to the Technical Secretariat MªJosé Bartolomé. After sending this fax you will receive an invoice. Upon receipt of both a valid registration form and payment, a registration confirmation will be send to you. Requests received after September 15 are subject to availability. Cancellation If the Working Group decides to cancel the congress, the full registration fee will be refunded.in the event that a participant wishes to cancel his registration, a written confirmmation is required. A refund of fees will be made, less a 25% administration charge, up to September 15. After this date no refund will be made for cancellations.

4 PAYMENT All registration fees are quoted in Euro and VAT is included. All fees have to be paid before the meeting. Payment can be made by Bank transfer. BY BANK TRANSFER: It is necessary to have a copy stamped bank transfer form attached to the official completed registration form. Fax or mail to: EUROTHROMBOSIS SCIENCE Barcelona, Cardiovascular Research Foundation Avda. Sant Antonio Mª Claret, 167 Hospital de la Santa Creu i Sant Pau- Pabellón del Convento Barcelona, Spain. Fax: mbartolome@csic-iccc.org Please transfer fund to: CAIXA D ESTALVIS I DE PENSIONS - LA CAIXA Bank code: 2100 Branch code: Bank identity: 87 - Account N : SWIFT: CAIXES BBXXX IBAN Account Number: ES (Imperative for international bank transfers)

5 OFFICIAL LANGUAGE English for oral presentations, slides and posters HOUSING Below, please find some suggestions about student s residences and a link where you can find hotels for your stay in Barcelona. Link: pacifico on line - hoteles - Student s residences: Albergue Residencia PERE TARRES Fundación Pere Tarrés c/ NUMANCIA, BARCELONA alberg@peretarres.org Residencia Universitaria LA CIUTADELLA PASSEIG PUJADES, Nº BARCELONA Tel resa@resa.es Residencia Universitaria CAMPUS DEL MAR PASSEIG SALVAT PAPASSEIT, Nº BARCELONA Tel resa@resa.es Teléfono: (central de reservas) Residencia Universitaria TORRE GIRONA PASSEIG DELS TIL LERS, Nº BARCELONA Tel resa@resa.es Teléfono: (central de reservas)

6 Residencia d INVESTIGADORS (CSIC) C/ HOSPITAL, Nº BARCELONA Tel resa@resa.es Teléfono: (central de reservas) TRANSPORT To go from the Prat Airport to Barcelona city center (Plaza Catalunya): By Bus, every 15 minutes First departure from the Airport: L-D/F:6.00 h. Last departure from the Airport: L-D/F:01.00 h. First departure from Pl. Catalunya: L-D/F:5.30 h Last departure from Pl. Catalunya: L-D/F: h - Price: Single ticket 3,75 Roundtrip ticket 6,45 You can buy the ticket inside the bus. It takes 30 minutes approximately - Stops: Plaça Catalunya, In front of a Department Store called El Corte Ingles Pg. Gràcia/Diputació-Av. Roma/Comte d'urgell- Estación de Sants (Sants Station)- Pl España/Creu Coberta-Airport (terminal A) - Airport (terminal B) - Airport (terminal C) - Pl. España (Spain Square - Venecian Towers) - Gran Via Corts Catalanes/Comte d'urgell - Pl Universitat (University Square)- Pl Catalunya (Catalonia Square)

7 EUROTHROMBOSIS SCIENCE 2008: FOCUS IN ATHEROTHROMBOSIS Intense scientific research has led to our current understanding that atherogenesis, lipids and other risk factors inflammation, coagulation, platelets, fibrinolysis and atherosclerosis progression are closely linked. This is the reason why the Working Group on Thrombosis of the European Society of Cardiology chose to organize the Eurothrombosis 2008 to foster an intense interdisciplinary discussion among clinicians and basic scientists working in the field about their latest perceptions of atherothrombotic mechanisms. Our aim is to facilitate the transition of the new understanding of atherothrombosis from bench to bedside and the translation of current state of the art knowledge into general clinical practice. This congress is an activity of the Working Group on Thrombosis of the European Society of Cardiology. Scientific Committee PROF. K. HUBER FESC - VIENNA, A DR F. ANDREOTTI FESC - ROMA, I DR. S.D. KRISTENSEN - AARHUS, D PROF. K.A. FOX FESC - EDINBURG, GB PROF. L. BADIMON - BARCELONA, SP PROF. H. ARNESEN - OSLO, N PROF. R. DE CATERINA - CHIETI, I PROF. D. GULBA - DÜREN, D PROF. P.G. STEG - PARIS, F PROF. F.W.A. VERHEUGT - NIJMEGEN, NL

8 REGISTRATION FORM Please Fax or this form to EUROTHROMBOSIS Barcelona Fax: +34 (93) mbartolome@csic-iccc.org Family name: Male Female First name: Fellow / cardiologist in training: Yes No Member of the Working Group on Thrombosis: Yes No Institution: Postal address: Zip code: City: Country: Telephone: Fax: Registration Standard registration (before September 15: 200- after September 15: 250,-) One day ticket ( : 50,-) December 11 One day ticket ( : 50,-) December 12 One day ticket ( : 50,-) December 13 Please fax this form before October 17 to: Technical Secretary MªJosé Bartolomé After sending this fax you will receive an invoice. Upon receipt of both a valid registration form and payment, a registration confirmation will be send to you. Requests received after September 15 is subject to availability.

9 ABSTRACT SUBMISSION Abstract submission and selection 1. Send your abstract as attachment to an message to: object: EUROTHROMBOSIS 2008 (ABSTRACT) 2. Clearly mention the name, institute, address, telephone number and fax number of the presenter in the message. 3. Abstract must be received by May 30, All abstracts will be reviewed by the Organizing Committee. The final selection will be made November Between November an message will be sent to all abstract submitters informing the status of their abstract (rejected or submitted). 6. Registration fee will be waived for the presenting author of each accepted abstract.

10 1. Use a MS-Word format. 2. The abstract must be in English. Abstract instructions 3. 1 A4 page, 2 cm (3/4'') margins, Title (Arial 12), Text (Arial 10) underline name of the presenting author, give address 4. The abstract (body text, table/figure) may not exceed 400 words. 5. One simple table or figure (neat and in black-and-white) may be included at most (each representing 50 words). So in case a table or figure is included, the body text may not exceed 250 words. 6. Mention 3 key words (consult the biannual list of keywords in Circulation). 7. The use of standard abbreviations is desirable. Place special or unusual abbreviations in parenthesys after the full word the first time it appears in the body text. 8. Use numericals to indicate numbers, except for the beginning of sentences. 9. Organize your abstract as follows: - Title (capitalize entire title, do not underline) - Author (omit degrees and titles) - Affiliations (list immediately after the last author, omit full address) - Body text (purpose, methods, results and conclusion) NOTES: The Organizing Committee of EUROTHROMBOSIS 2008 reserves the right to refuse any abstract if the scientific content is deemed insufficient. According to topic, selected abstracts will be presented either as oral communication or as poster. Notice regarding type of presentation will be forwarded to authors on July 15th Forward abstract form by at mbartolome@csic-iccc.org and copy of appropriate bank remittance by fax to: Abstract submission will not be processed without registration. Presenting authors will be informed by about abstract acceptance. Conference room will be equipped with computer and projector.

11 THURSDAY 11 th December :30 REGISTRATION 15:00 WELCOME Prof. L. Badimon (Spain) / Prof. K. Huber (Austria) 15:30-17:00 SYMPOSIA What are clinical results teaching us on platelet function and thrombosis Chair: Prof. K. Huber (Austria) Prof. C. Macaya (Spain) 15:30 Anti platelet treatment: Synergies or conflicts? Critical evaluation of trial data Prof K.A.A.Fox, Edinburgh (UK) 15:50 What is it GRACE teaching us? Prof. D. Gulba, Düren, (Germany) 16:10 Bleeding: Impact and Consequence Prof. P.G. Steg, Paris (France) 16:30 Why is it better to open mechanically than lyse pharmacologically? Prof. S.D. Kristensen, Aarhus (Denmark) 16:50 DEBATE and COFFE 17:00-18:30 ORAL COMMUNICATIONS 18:30-20:40 SYMPOSIUM LILLY 20:45 Dinner Party

12 FRIDAY 12 th December :30 LECTURE Chair: Prof. S.D. Kristensen Stent thrombosis and in-stent restenosis: Mechanisms Therapeutics Clinical Results Prof. K. Huber (Austria) 10:00 11:00 SYMPOSIA Questions without response Chair: Prof. P.G. Steg (France) Prof. J.J. Badimon (USA) 10:00 Hemoglobin and NO Prof. F. Andreotti, Roma (Italy) 10:20 Revisiting Aspirin and thienopyridine resistance Prof. R. De Caterina, Chieti (Italy) 10:40 Estrogen therapy: Why and when? Prof. F.W.A. Verheugt, Nijmegen, (Netherland) 11:00 DEBATE and COFFEE 11:30-12:30 SYMPOSIA Cell therapy: The hope Chair: Prof. K.A.A. Fox (U.K) Prof. JF. Martin (UK) 11:30 Intracoronary injection of autologous mononuclear bone marrow cells: Pros and Cons Prof. H. Arnesen, Oslo (Norway) 11:50 Cell therapy: options and trends Prof. Fernández-Avilés, Madrid (Spain) 12:10 DEBATE

13 12:30 LECTURE Chair Prof. H. Arnesen (Norway) Prof. C. Patrono (Italy) 13:00 LUNCH Magnetic resonance imaging: Is it ready for the vessel wall? Prof. JJ. Badimon, New York (USA) 14:30-16:30 SYMPOSIA Mechanisms in Atherothrombosis Chair: Prof. R. De Caterina, (Italy) Prof. P. J.Grant, (UK) 14:30 Platelet function Prof. J.A. Jakubowski, Indianapolis, (USA) 14:50 Omega-3 fatty acids in atherothrombosis Prof. I. Seljeflot, Oslo (Norway) 15:10 CD-36 in atherothrombosis Prof. J. McGregor, London (U.K) 15:30 From obesity to atherothrombosis; are adipokines the culprits? Prof. J. Wojta, Vienna (Austria) 15:50 The case of Cox-2 and Coxibs in cardiovascular disease Prof. C. Patrono, Rome (Italy) 16:10 HDL in Atherothrombosis Dr. B. Ibañez, Madrid (Spain) 16:20 DEBATE and COFFEE 17:00-18:30 ORAL COMMUNICATIONS 18:30 END OF SESSION 21:00 DINNER

14 SATURDAY 13 th December :30 ORAL COMMUNICATIONS 10:30-11:00 SYMPOSIA New targets-i Chair Prof. F.W.A. Verheugt (Netherland) Prof. F. Andreotti (Italy) 10:30 Ischemic protection fact or fiction? Dr. D. García-Dorado, Barcelona (Spain) 10:50 Proteomics in atherothrombosis Dr. T. Padró, Barcelona (Spain) 11:10 DEBATE and COFFEE 11:30-13:00 SYMPOSIA New targets-ii Chair Prof. D. Gulba, (Germany) Prof. L. Badimon, (Spain) 11:30 Angiogenesis in atherothrombotic plaques Prof. M.Slevin, Manchester/Barcelona (U.K/Spain) 11:50 Biorevascularization Prof. JF. Martin, London (UK) 12:10 DEBATE, COFFEE and SNACKS 12:30 CLOSING REMARKS Prof. L. Badimon (Spain) / Prof. F. Andreotti (Italy) Research and Development in Europe. The case of Ireland Prof. D. Fitzgerald, Dublin (Ireland) 12:50 END OF CONGRESS

15 ORGANIZE BY UNDER THE AUSPICES OF Grupo de Trabajo de Trombosis Mediterranean League against Thromboembolic Diseases FUNDED BY SPONSORS

OPTIONS OF COLLABORATION

OPTIONS OF COLLABORATION 1 INDEX Pages. Welcome 3. Committees and Organization 4. General Information 5-6. Objective of the collaboration 7. Sponsorship 8. Specific Sponsorship opportunities 9. Exhibition