1 New Investigator Research Grants Guidelines and Application Package Deadline: January 20, 2015 Guidelines: Overview Through its National Grants program, The Hospital for Sick Children Foundation ("SickKids Foundation") seeks to strengthen Canada s capacity and knowledge to respond to children s health challenges and needs. To do so, we grant funds to research projects that have the potential for significant impact in areas of children s health needs based on scientific excellence and relevance to child health. Funding Objectives New Investigator Research Grants provide important early career development support to child health researchers. It is intended this program will enhance the grant recipient s ability to compete with more senior investigators for research grants from other funders. Through this grants program we are seeking to fund research carried out by new investigators across Canada who successfully lead, participate in, and translate outstanding child health research that will respond to children s health challenges and needs. The New Investigator Grants Program is a jointly sponsored program of SickKids Foundation and the Canadian Institutes of Health Research ("CIHR") - Institute of Human Development, Child and Youth Health (IHDCYH). Grant recipients may obtain up to three years' support for research in biomedical, clinical, health systems and services, and population and public health sectors. New Investigator Guidelines and Application Package Page 1
2 Funding for Research Operating Grant New investigator researchers may obtain up to a maximum of $100,000 annually for up to three years for a maximum of $300,000 for their research project. The research operating grant may be used for: Research costs materials, services, salaries of staff including research assistant /technicians etc, knowledge translation or dissemination of results, travel, supplies, resources, animals. Equipment purchase or rental (including computers) required for the project up to $10,000 total including set-up. Funding is paid to a Canadian institution that is a registered Canadian charity that the principal investigator has a formal affiliation with and agrees to administer the grant funds (the "Eligible Institution"). We are unable to fund projects: That has limited relevance to the health of children (conception up to 18 years of age). Primarily to the benefit of children outside of Canada. That are otherwise funded research projects. Applications in which the principal applicant: o is a trainee (i.e. a fellow or doctoral candidate); o does not have an affiliation with an Eligible Institution; o currently holds an active SickKids Foundation grant. Funding is contingent upon availability of funds by both SickKids Foundation and the CIHR s Institute of Human Development, Child and Youth Health. Who is Eligible to Apply The principal investigator must be eligible to apply for independent research grants and be formally affiliated with an Eligible Institution, where that institution is willing to financially administer the grant. The principal investigator will usually hold a doctoral degree (Ph.D) or equivalent medical/health care degree and have had formal research training. Co-principal investigators are researchers who may or may not have a formal affiliation (faculty appointment) with the Eligible Institution, but will take responsibility for particular administrative and scientific aspects of the research project. Trainees (i.e. doctoral students or fellows) cannot be principal or co-principal investigators. New Investigator Guidelines and Application Package Page 2
3 Eligible applicants are required to include a mentorship plan and to work with a clearly-identified mentor. The mentor will work with the applicant on a plan; review the application before submission; provide advice throughout the project to ensure it is competitive in terms of both scientific excellence and relevance to child health. The applicant must be a new investigator at the date of application; i.e. at the time of application deadline of January 20, For the purpose of this award, a new investigator is defined as an individual who: As a principal investigator has not been awarded combined Operating Grant funding of $500,000 or more Canadian dollars. An "Operating Grant" is defined as a grant that can be used to cover administrative or any other research-related costs (including salary of trainees or students) in order to carry out a research project. This does not include start up, equipment or infrastructure funds. Note: Should an Operating Grant be received after the application is submitted, the applicant must notify SickKids Foundation immediately. Is within five years of their first academic appointment. Academic appointment is defined as an appointment which allows an individual to apply for research grants as an independent investigator. Note: If the principal investigator is a health care practitioner who does not have an academic appointment, then they must be formally affiliated with an Eligible Institution to perform research as a principal investigator and is willing to financially administer the grant. Has at least 50% of protected research time for the duration of the project. Conditions for Grant Whether there is one or two principal investigators applying for funding for a project, both must qualify as new investigators. Co-applicants who are not the principal investigator(s) are not required to be new investigators. A maximum of two principal investigators will be permitted per application. New Investigator Guidelines and Application Package Page 3
4 If in doubt about your status as a new investigator, please contact SickKids Foundation. SickKids Foundation reserves the right at its sole discretion to make the final determination as to whether, for the purposes of eligibility, an applicant will be considered a new investigator. We recognize that applicants can co-submit projects to other agencies for funding support. If funding is awarded from another agency in full or in part of the funding awarded from SickKids Foundation, the applicant would no longer be eligible for this grant. SickKids Foundation reserves the right to make the final funding decision. Only one proposal may be submitted by a principal investigator per funding round. In order to best address the diverse range of paediatric expertise represented in our peer reviewers process we ask that you write the proposal using accessible language geared to the knowledgeable non-expert. Applications should be written in language appropriate for review by paediatric scientists with primary expertise in other domains. A signed and duly completed New Investigator Research Grants Grant Application for Project Support and Summary Sheet must be submitted. The application and summary sheet can be found at Any equipment purchased with grant funds are to be property of the Eligible Institution where the grant funds are held. Projects must adhere to ethical standards of SickKids Foundation, CIHR and the Eligible Institution. Grantees are responsible for making sure that their Research Ethics Approval (REB) and/or Animal Care Approval are up to date, and Health Canada approval, if required, is in place. In addition: If a project involves research on humans it must be in accord with the Tri- Council Policy Statement on Ethical Conduct for Research Involving Humans (for more information please visit the following website: eptc2/default/). New Investigator Guidelines and Application Package Page 4
5 If a project involves research on animals it must be comply with guidelines of the Canadian Council on Animal Care. If a project involves research handling biological and chemical hazards it must meet CIHR "Guidelines for the Handling of Recombinant DNA Molecules and Animal Viruses and Cells." To be awarded as a grant recipient, the Principal Investigator(s) and Eligible Institution must sign a Grant Agreement in the form provided by SickKids Foundation, in its sole discretion. Grant recipients must provide a report on the project funded by this grant as requested by SickKids Foundation, including, without limitation, an annual progress report that includes a financial statement produced by the Eligible Institution. SickKids Foundation and CIHR must be given credit in publications, presentations or communication activities including media, symposia, research reports and promotional events arising from work funded by this grant. Grant recipients shall notify SickKids Foundation of any dissemination activities that they undertake from the project funded by this grant, including any symposia, conferences and any other promotional events. From time to time the grant recipient will be requested to complete a survey in order help measure the impact of the program. Any unexpended funds are to be returned to SickKids Foundation. Recognition of a break in the research career Individuals who have taken time off for personal reasons or for other reasons (such as to establish a private clinical practice, family or health reasons, or parental leave) within the first five years of their research career may be considered a new investigator. These individuals must include a letter documenting the duration of the interruptions and indicating whether or not there was any research productivity during that time. This time off will not count towards the five years. Please note that time spent doing industry or government research will count towards the five years. SickKids Foundation reserves the right to make the final determination as to whether an individual is eligible to apply. New Investigator Guidelines and Application Package Page 5
6 Assessment and Relevance Criteria Projects must be relevant to SickKids Foundation s Mission to improve the lives of children and their families in Canada and around the world. Funding decisions will be based on scientific merit as well as relevance to the following criteria: The number of children affected; The potential for direct impact on the care of children; Lack of knowledge on the topic; High incidence or high morbidity/mortality; and Highly relevant to the quality of life of children. To be considered for funding, applications must demonstrate that the proposed research will be collaborative across disciplines and include an appropriate translation and knowledge dissemination/uptake plan for the research findings. As well, we are seeking applications from across research methodologies (quantitative, qualitative, and mixed-methods) and research sectors (biomedical, clinical, health systems and services, and population and public health sectors). In addition, CIHR's Institute of Human Development, Child and Youth Health s mission is to promote and support research that improves the health and development of mothers, infants, children, youth, and families in Canada and throughout the world. The Institute has four Strategic Research Priorities that can be consulted at: Applications should be relevant to at least one or more of IHDCYH s strategic priorities. Proposals must demonstrate excellence with respect to research design, methodology, instrumentation, statistical analysis and project outcome measurement. Projects that show a high degree of innovation and incorporate a multi-disciplinary approach will be favored. Knowledge Translation SickKids Foundation is committed to advancing children s health and therefore support of Knowledge Translation is an important investment in ensuring that funded research will have impact on child health practices, policies and/or further research. New Investigator Guidelines and Application Package Page 6
7 To be eligible for consideration, applications must include a Knowledge Translation (KT) plan. The objectives of the KT plan are to ensure that the research is translated appropriately to relevant stakeholders and potential endusers. Up to 15% of the research operating grant may be used for knowledge translation activities. To assist in the development of your KT plan, we encourage you to use the Knowledge Translation resources available by going to the webpage and clicking on Knowledge Translation Resources for Researchers. Resubmissions A new investigator applicant who did not receive funding may submit a revised application in a future competition, providing they still meet eligibility criteria. A maximum of one resubmission is permitted per project. New investigator applicant(s) of a resubmission should provide a letter (no longer than two pages) to the Grant Review Committee addressing itemized concerns raised by reviewers. Resubmissions will be assessed under the same criteria as first-time applications but with special attention to the responses to reviewers comments. Review and Selection Process The selection process is based upon expert peer review. The Grant Review Committee will critically evaluate each grant application for scientific merit and relevance to child and youth health based on the funding criteria. Also to be considered in the assessment will be the potential impact as well as institutional and mentorship support. Overall budget and knowledge translation plan or dissemination of results as applicable are carefully reviewed. Final approval, based upon recommendation from the Grant Review Committee, rests with SickKids Foundation's Board of Directors. Please note that SickKids Foundation reserves the right to reject any application at its sole and unfettered discretion at any time. If you are selected as the recipient of a grant, any breach of these Guidelines at any time shall result in termination of the grant and the requirement to immediate return the awarded grant funds. Applications written in French are welcomed. Acknowledgement of receipt of application will be ed to all new investigator applicants within 10 working days of the deadline. If you do not receive an acknowledgement of receipt within 10 days please contact the Foundation. Applicants can expect to be notified of the funding decision by June New Investigator Guidelines and Application Package Page 7
8 Application Package: Submission Procedure and Deadline Date for Applications Applications deadline is 5:00 pm EST on January 20, Application Package to be ed in one document (pdf is fine) to (and send one original, signed hard copy) This competition is highly competitive with a limited funding envelope. All applicants should contact their institution s research awards or grants management office to discuss any potential internal process that may be required that will enhance the strength of their application. In order to best address the diverse range of paediatric expertise represented in our peer reviewers process we ask that you write the proposal using accessible language geared to the knowledgeable non-expert. Applications should be written in language appropriate for review by paediatric scientists with primary expertise in other domains. Please ensure all required documentation is included before submitting your application. 1. Grant Summary Sheet (1 page maximum) which must be included in the main application, is also to be ed as a separate standalone document in word format to 2. Application Package compiled, including the grant summary sheet, into one document (pdf is fine) and ed to 3. Please mail (or courier) one original signed hard copy of the completed application. New Investigator Guidelines and Application Package Page 8
9 New Investigator Research Grants - Applicant Checklist Please check off what has been included in this application and attach this checklist. Mandatory Attachments The following must be submitted by the deadline: 1. Grant Summary Sheet (1 page maximum), which must be included in the main application and ed as a separate standalone document in word format to 2. Application Package please the complete application package in one document (pdf is fine) to (and send one original, signed hard copy). Resubmission? If yes, include your two page cover letter New Investigator Applicant Checklist (this document) New Investigator Grant Application Form (maximum 20 pages), including: A maximum of 8 pages total in length for Research Components (questions 13 17) Knowledge Translation Plan (Question 18) Mentorship Plan (Question 19) Application Appendices (maximum 15 pages, excluding CVs) Full curriculum vitae (CV) for principal investigator applicant(s) (must be CIHR/common CV format) and for co-applicants (CIHR registration CV) Curriculum vitae (CV) for Mentor (no specific format requested) Budget Justification up to a maximum of 5 pages Support Letter from Department or Division Head Letter documenting a break in research career if applicable Optional attachments including charts and diagrams up to a maximum of 5 pages Necessary Approvals are mandatory for projects involving human or animal subjects and natural health products (these approvals may be obtained after application is successful: ATTACHED PENDING NOT APPLICABLE Ethics Approval Animal Care Approval Health Canada Approval Incomplete applications will not be considered for funding. New Investigator Guidelines and Application Package Page 9
10 Grant Application Summary Sheet (one page maximum) This summary sheet must be included with the application and submitted separately as a standalone document, in word format, from the application package. Short Project Title: New Investigator Applicant & Sponsoring Institution: Co-Applicants & their institutions: Project Dates & Duration: Research Operating Budget Summary (up to $100,000 per year for up to 3 years): Year 1: $ Year 2: $ Year 3: $ Total: $ Project outline in lay language, under the following headings: Background Specific Objectives Hypothesis Methods Expected Results New Investigator Guidelines and Application Package Page 10
11 Grant Application Questions This form is not to be used per se, but the numbering and heading system shown herein must be replicated, please use 12-point font size and the text of the proposal may be single-spaced and can be printed double sided. The total length of the application must not exceed 20 pages, excluding appendices and references. A maximum of 8 pages total in length will be considered for Research Proposal Components (questions 13 17). Research Sectors (please check which research sector applies to your project) Biomedical Health Systems and Services Clinical Population and Public health Please answer all questions 1. Name of Sponsoring Institution (i.e. the institution where the funds would be held if the grant is awarded): 2. Revenue Canada Charitable Registration Number for the sponsoring institution (All hospitals and universities have a Charitable Registration Number, which has the form xxxxx-xxxx-rrxxxx; contact the development office at your institution if you are having difficulties identifying this number): 3. Acceptance of a grant constitutes agreement that the requirements and conditions governing the award of a grant by The Hospital For Sick Children Foundation as set out in the New Investigator Research Grants Guidelines for Applicants as posted on SickKids Foundation`s website are hereby accepted by the Principal applicant(s) and the Sponsoring Institution. 4. Principal New Investigator applicant(s) name: Title and Department: Area of expertise: Full mailing address: Telephone number Signature and Date of Application: 4. Department or Division Head name at Sponsoring Institution: Title: Signature: 5. a) Co-applicants(s) of the project, including name, title, department, area of expertise, telephone number and for each: b) Project Mentor, including name, title, department, area of expertise, telephone number and New Investigator Guidelines and Application Package Page 11
12 6. a) Short Title of Project: b) Area of Project Research: 7. Project Duration: 8. a) Where will the project be carried out? b) Will the participation of other institutions or agencies be required? If yes, please list these institutions/agencies and attach letters indicating their agreement to participate. 9. If this is a revised, resubmitted application, please provide the original SickKids Foundation file number and the two page cover letter addressing reviewers concerns. 10. Has an application been made to any other agency (agencies) for support of this project? If yes, give names and amounts requested. If a decision is still pending, include grant deadline dates for the submission. 11. Does the project involve human and/or animal experimentation or clinical examination of patients? If yes, append approval by an appropriate Ethics Committee, or ensure that the Foundation receives a copy of the approval within 60 days if proposal is approved. 12. Person who will administer the funds (this should be someone in the research accounting office) on behalf of the sponsoring institution: Name: Title and Department: mailing address: telephone number and Signature: Research Proposal Components Please write this section using accessible language appropriate for review by paediatric scientists with primary expertise in other domains. Please respond to the following questions (13 17 with a maximum of 8 pages total in length, not including references). Refer to our assessment criteria in the Application Guidelines in responding to these questions. In the references, any articles to which the new investigator(s) applicants have contributed must include a complete authorship list. New Investigator Guidelines and Application Package Page 12
13 13. State what and how the objectives of the project are relevant to the improvement of child health in Canada. 14. Outline the present state of knowledge and provide a brief review of the literature relevant to the proposed project. 15. Indicate relevant work on related projects by the new investigator applicant(s) and others in your health sciences centre or region. (Include references to pertinent publications). 16. Provide an outline of the proposed project including the methodology and research design. Documentation should include rationale for the choice of measuring instruments/scales as well as documentation of those not in standard use. 17. What criteria will be used to measure whether the objectives have been achieved, and how (in some detail) will they be applied? 18. Provide your Knowledge Translation (KT) plan. Please see the KT guide and plan development tool provided at: and clicking on Knowledge Translation Resources for Researchers. (Note that up to 15% of your budget may be used to support your KT plan). 19. Mentorship training plan to a maximum of one page describing the current relationship with your mentor, the details of the mentoring plan and a description of the training environment. 20. Your overall project budget should include the following information: expenses in each year, total project budget, and total requested from SickKids Foundation CIHR IHDCYH, and also show any funds being requested from other sources. Appended budget justification up to a maximum of five pages. New Investigator Guidelines and Application Package Page 13
14 Example: Budget Item Year 1 Year 2 Year 3 Project total Salary for Research Coordinator (.5 FTE) $18,720 $18,720 $18,720 $56, hrs./wk x $18/hr Photocopying $600 $600 $600 $1,800 Travel to conferences $2,000 $2,000 Computer & Equipment $10,000 $10,000 KT plan activities (up to 15%) $15,000 $15,000 $15,000 $45,000 Continue to list all line items Total research operating maximum: $100,000 $100,000 $100,000 $300,000 Ensure that expenses are clearly linked to the project activities described in the application. To ensure reviewers can properly assess your proposal, you are encouraged to attach a budget justification (to a maximum of five pages). Any line items that are not justified may be removed. If this grant request is for partial project support from this grant program, please provide full details of other funding sources. Itemize the following, if applicable, in the budget: All personnel to be engaged in project, including titles and information on hourly wage, as well as yearly salary and benefits Equipment required for project Supplies and/or office expenses Other expenses (give details). Appendices Curriculum Vitae Please include FULL CV s for each principal investigator. The CV s must be CIHR/Common CV format. For the co-applicants please submit CIHR registration CV s (submitting a non-cihr formatted CV may invalidate your submission). Access to the CCV website: Curriculum vitae (CV) for Mentor (no specific format requested) Budget Justification (maximum of 5 pages) New Investigator Guidelines and Application Package Page 14
15 Institutional Support All applications must be accompanied by a letter of support from the applicant's Department or Division Head of the Eligible Institution. This letter must indicate the ways in which the institution will support the applicant, in terms of resources (lab space, computer hardware, etc.), mentorship and research time for the applicant. If the principal investigator is a Medical Doctor or Health Care Clinician, the letter from the individual's Department or Division Head must also guarantee that at least 50% of the applicant's time will be protected for research for the duration of the project. Please see the new investigator applicant checklist for instructions on what to include in the appendices. Application Appendices (maximum 15 pages, excluding CVs) **N.B.** Please note that you must include all essential information pertaining to the project in the body of the application and not in the appendices. The application will be seriously disadvantaged if the reviewers do not find the project information complete and satisfactory. An electronic copy of the complete and signed application page must be compiled and received in one document (.pdf is fine) to One Original hard copy of the application must be mailed or couriered to: National Grants SickKids Foundation 525 University Avenue, 14 th Floor Toronto, ON M5G 2L3 Telephone: x2354 The hard copy of the application can arrive after January 20, as long as the version is received by the deadline. New Investigator Guidelines and Application Package Page 15
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