One project will be funded. Successful pilots will receive up to $10,000, to be spent within a 6 month project period.
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1 Center for Research on Substance Use and Addition (CRSUA) and Clinical and Translational Science Institute (CTSI) Request for Applications for Team Ignite Pilot Awards Purpose The CRSUA and CTSI are seeking applications for pilot projects. The goal of these projects is to foster new scientific collaborations that help address the opioid epidemic and related problems. Projects must test generalizable solutions to translational research problems. Please note that hypothesis-testing research studies that aim to test a single strategy or technique will not be considered responsive to this RFA. One project will be funded. Successful pilots will receive up to $10,000, to be spent within a 6 month project period. Successful proposals will: Foster NEW scientific collaborations (multi-disciplinary) that address the opioid epidemic and related problems Demonstrate a connection to the CRSUA Opioid Ignite Event. Provide a rationale for local relevance and potential for generalizability. Lay out a reasonable project plan that is feasible to complete in the 6 month project period as there will be no opportunity to request carryover. Eligibility These awards are open to all faculty with a rank of instructor or higher from Wake Forest (Health Sciences & University). The award is designed to encourage team science, or the collaborative effort of professionals trained in different disciplines and working together to address a scientific challenge. The scientific team must be newly formed, or if already existing, must add professionals from new disciplines. A member of the Key Personnel must have attended the CRSUA Opioid Ignite Talk event to be eligible for funding. Key Dates Date Detail 08/31/17, 11:59 pm Full Application Deadline 09/22/17 Selection of Awardees 10/01/17 Project Start Date 03/31/18 Project End Date Funding The CRSUA and CTSI will fund up to $10,000 in direct costs per project. See section on Budget Guidelines for more details on allowable and non-allowable budget items. Requests for no-cost extensions will not be approved. Application Procedure Full Application Deadline: 8/31/17, 11:59 pm Investigators can apply with through the following epilot application link by 8/31/17. Application instructions are included in the epilot system and summarized below. Format Specifications Arial font and no smaller than 11 point Margins at least 0.5 inches (sides, top and bottom) Single-spaced lines Consecutively numbered pages Submission/Applicant Information Project Title Submitting Investigator, Co-Investigator(s), and other Key Personnel information
2 Abstract (300 words max) Research Plan (4 pages max) Specific Aims Background and significance, translational importance, experimental design and methods, dissemination and implementation plan Study milestones and anticipated outcomes Contribution and summary of qualifications of each contributing investigator Project Timeline (1 page limit, examples can be found in Appendix I) References (no page limit) Team Composition and Event Impact Address the following statements/questions within the epilot application system. Please describe how your proposal was impacted/inspired by attendance at the Opioid Ignite Talk event. Which of the investigators on this proposal have previously collaborated on at least one research project? Which are the connections that represent new collaborations? Which are the investigators who are new to conducting research in this area? Did any of the new collaborations result from the Opioid Ignite Talk? Describe how the new collaborations were formed. Information Regarding Human Subjects and Live Vertebrates Address the following if the project involves human subjects. IRB Approval Status (please note: IRB approval is not required for full application submission) Address the following if the project involves live vertebrates. IACUC Approval Status (please note: IACUC approval is not required for full application submission) Budget and Justification (budget template plus 1 page justification) Complete the budget template form provided along with a brief justification for the funds requested for this RFA. Please include explanation of other resources that may be leveraged to support the project. Sub-awards to other institutions to carry out work on a project are not permissible. NIH-style biographical sketch for all Key Personnel (new style) Budget Guidelines The budget period is for 6 months beginning 10/1/17 and ending no later than 3/31/18. Up to $10,000 in direct costs may be requested. Grant funds may be budgeted for: Research support personnel (including undergraduate and graduate students) Travel necessary to perform the research Small equipment, research supplies and core lab costs, or Other purposes deemed necessary for the successful execution of the proposed project Grant funds may not be budgeted for: Salary support for the PI or faculty collaborators Office supplies or communication costs, including printing Meals or travel, including to conferences, except as required to collect data Professional education or training
3 Computers or audiovisual equipment, unless fully justified as a need for the research Manuscript preparation and submission, or Indirect costs Awarded funds must be used to conduct the work proposed. All direct charges to this award must adhere to federal regulations and requirements regarding the use of CTSA funds. The CRSUA and CTSI reserves the right to revoke funding in the event it is determined that funds were not spent in accordance with the approved protocol. The general criteria for determining allowable direct costs on federally sponsored projects is set forth in 2 CFR Part 200: Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (The Uniform Guidance). Review Criteria and Process Proposals are competitive and peer reviewed. Proposals will be evaluated by CTSI Team Science Program Leadership plus an additional functional expert and based on NIH review criteria and scoring. Reviewers will score applications from 1 to 9 based on: 1. Significance of the problem to be addressed; 2. Innovation in the proposed solutions; 3. Strength and breadth of the investigative team; 4. Methodological rigor and feasibility with clear milestones; 5. Likelihood the innovation will be broadly applicable and have impact on translational research, and; 6. A reporting plan regardless of whether the study yields positive or negative results; 7. Other elements to be considered in the review include: the likelihood of the multidisciplinary team to increase the impact of the project, the likelihood that the investment will lead to external funding or a licensable innovation, early-career faculty involvement, race/gender inclusiveness of the research team and inclusion of women, minorities, older adults and children as potential participants. Program Expectations Participate in team kick off meeting on team training Meet with Team Science Leadership every 2 months to review progress and address barriers Upon completion of the project: o Close-out report with plans for implementing and disseminating innovations o Presentation of findings at requested CRSUA and/or CTSI events Disclosure of implementation/dissemination results and efforts to seek extramural funding beyond the pilot grant and subsequent notification of any funds obtained and/or related publications or significant collaborations from the project for a minimum of 4 years. Other Guidelines 1. Prior to receiving funds, research involving human subjects must have appropriate approvals from the IRB. Either an IRB approval letter or an IRB response to a Determination Whether Research or Similar Activities Require IRB Approval must be submitted prior to funds being released. Human subjects must be reviewed in accordance with the institution s general assurances and HIPAA. All key personnel must have certification of training in the protection of human subjects prior to the start of the grant period. 2. Prior to receiving funds, research involving live vertebrates must have appropriate approvals from IACUC. Either an IACUC approval letter or documentation on why activity does not require IACUC approval must be submitted prior to funds being released. 3. We expect PIs to report over the lifetime of the work the outcomes achieved due to the pilot award, e.g., subsequent external funding, publications, presentations and patents. 4. All publications that are the direct result of this funding must reference: Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publications must also be registered in PubMed Central. 5. Any awardee who leaves his or her position should contact the CRSUA and CTSI to discuss future plans for the project.
4 Grant Administration The Principal Investigator is responsible for the administration of grant funds. Projects will be for a 6 month period of time. Contacts Questions about your research project should be directed to Mark Wolfson at mwolfson@wakehealth.edu. Questions about the epilot electronic submission system should be directed to Mike Laliberty at mlaliber@wakehealth.edu.
5 Appendix I Below are examples to show different methods to provide study milestones, outcomes, and timeline. However, these formats are not required. Example 1: Milestone 1 (0-1.5 months): Milestone 1 Details Outcome: Outcome 1 Details Milestone 2 (1.5-4 months): Milestone 2 Details Outcome: Outcome 2 Details Milestone 3 (4-6 months): Milestone 3 Details Outcome: Outcome 3 Details Example 2: Month Activity/Aim/Milestone 1 Activity/Aim/Milestone 2 Activity/Aim/Milestone 3 Activity/Aim/Milestone 4 Activity/Aim/Milestone 5 Activity/Aim/Milestone 6 Example 3: Aim Milestone Month 1-3 Month Milestone 1 Milestone 2 Aim 1 Anticipated Outcomes: Detail Aim Milestone Month 1-3 Month Milestone 1 Milestone 2 Milestone 3 Aim 2 Anticipated Outcomes: Detail
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